In this episode of the Long COVID Clinical Podcast, hosted by Drs. Anita Chopra, Andrew Schamess, and Tiffany Walker, physician-scientist Dr. Linda Geng discusses the complexities of diagnosing and treating long COVID, the overlap with other infection-associated chronic conditions, and ongoing research efforts. Her clinical and research expertise sheds light on the heterogeneity of long COVID and potential therapeutic avenues, including the clinical approach to diagnosing long COVID and the current lack of biomarkers, phenotypic clusters and heterogeneity of long COVID patients, research directions such as repurposing drugs, pathobiology, and large-scale studies, strategies for rehabilitation and management of post-exertional malaise, and the importance of collective research efforts and future directions in long COVID care.

Edited and Produced by Christopher Chiu and Carissa Lee

This episode of the Long COVID Clinical Podcast, hosted by Drs. Anita Chopra, Andrew Schamess, and Aaron Friedberg, features Dr. Nikhil Kamat in a discussion of hematological complications in long COVID. Dr. Kamat, a clinical assistant professor at the University of Washington School of Medicine, shares his expertise on microclots and immune dysregulation, revealing why current diagnostics often miss microvascular damage. The discussion delves into the formation of microclots, their manifestation in organs, and the limitations of traditional tests like D-dimer. Dr. Kamat highlights the role of inflammation in endothelial damage and discusses who is most at risk for blood-related complications post-COVID. The episode also covers emerging treatment considerations, including the controversial idea of prolonged anticoagulation, and emphasizes the importance of balancing treatment risks. This insightful conversation offers critical knowledge for clinicians, researchers, and anyone interested in the long-term impacts of COVID, providing a pathway to more targeted therapies and better patient outcomes.

Edited and Produced by Christopher Chiu and Carissa Lee

In this episode of the Long COVID Clinical Podcast, hosts Andrew Schamess and Anita Chopra discuss recent research on Long COVID at Ohio State University. They are joined by Dr. Amal Amer, a Professor of Microbial Infection and Immunity, and Dr. Heba Amer, who works in Dr. Amal's lab. Dr. Amal shares her personal experience with Long COVID and details her research on the inflammasome and caspase-4/11, proteins linked to severe inflammation and cognitive issues in Long COVID. The discussion highlights the relationship between these proteins and the inflammatory response, potential coagulopathy, and how this research could lead to new treatments. Dr. Heba Amer describes using an advanced behavioral testing system for mice to study cognitive dysfunctions related to Long COVID. The findings offer promising avenues for drug discovery and a deeper understanding of Long COVID's pathology. Additionally, future research plans and the importance of correlating mouse model data with human samples are discussed. The episode concludes with optimism about ongoing and future research efforts.

Edited and Produced by Christopher Chiu