Dr. Veena Joy, the U.S. Lead for Strategic Partnerships in Allergy and Autoimmunity at Thermo Fisher Scientific discusses her career transition from academic research to industry work at Thermo Fisher Scientific. Driven by her interest in health economics and the underexplored aspects of autoimmune disease diagnostics, Dr. Joy transitioned to a focus on translational medicine and autoimmune diagnostics. Emphasizing the value of thinking beyond narrow specializations, Dr. Joy discusses how her diverse experiences have enabled her to make a broader impact in the autoimmune diagnostics field, particularly improvements in autoimmune disease diagnostics. The holistic diagnostic approaches Dr. Joy discusses include the consideration of factors like genetic predisposition, environmental triggers, and societal influences. In addition, health economics, the role of empathy and innovation in scientific advancements also play roles in a complete approach to diagnostics, with the ultimate goal being to improve patient outcomes.

Dr. Joy notes that, while diagnostic improvements have been ongoing for 20-30 years, there has been significant momentum in the past decade, particularly with advancements in CAR-T therapy, which holds promise for eliminating certain autoimmune diseases. More specifically, Dr. Joy discusses the potential of CAR T-cell therapy to revolutionize autoimmune disease treatment by re-engineering cells and removing certain autoimmune conditions.

Women face notable diagnostic challenges, like receiving timely and accurate diagnoses for autoimmune conditions when, for example, symptoms are dismissed as hormonal or not taken seriously by healthcare providers. Dr. Joy further notes that women tend to deal with symptoms on their own and that there are significant disparities in diagnosis rates between women and men, with women being diagnosed or misdiagnosed at higher rates despite comprising the majority of autoimmune condition patients. Addressing these issues to improve women's health and access to care, particularly for marginalized groups, is a major goal.

By focusing on improving diagnostic techniques and ensuring their value through health economics, Dr. Joy’s holistic approach to diagnostics is aimed at reducing those disparities. Educating clinicians and patients, as well as optimizing the use of existing diagnostic tests are part of this more complete picture.

Dr. Joy emphasizes the importance of empathy in science and highlights Thermo Fisher's commitment to innovation and patient care under CEO Mark Casper. With various challenges and opportunities in the scientific community, scientists must be collaborative changemakers by considering multiple perspectives and impacts of their work.

Episode Resources:

B·R·A·H·M·S Biomarkers for Preeclampsia Screening

Upcoming Micro-Lecture

—

Connect & explore more: Visit The Life of Her Mind to listen, share, and access links and resources. Check out Labroots scholarship opportunities here. Submit a scientific poster to be featured in our event(s) here.

Dr. Kellie Smith is an Associate Professor of Oncology in the Bloomberg-Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins School of Medicine. In this interview, Dr. Smith shares how she came to study science and specialize in T-cell immunology and immunotherapy. She also discusses how she developed an original assay for detecting anti-tumor immune responses in specific types of lung cancer, called MANASCORE. She also shares some details about the goal of comprehensively understanding immunotherapy-resistant immune cells. Dr. Smith reveals the basic thought process that led her to a focus on integrating multi-omics technologies to study tumor-reactive T cells in the setting of various cancer types, with a specific focus on lung cancer; what brought her to Johns Hopkins, and how remaining at the institution throughout her career been an asset to her research.

In a field that is highly technical and requires sustained, years-long dedication that some people could find draining or otherwise unrewarding — the big Hollywood moments are presumably rare. Dr. Smith describes how she paces herself, determines benchmarks, and frames big-picture questions that structure her work.

Finally, scientists have long worked at the center of the tension between advancing (empirical) knowledge, and the realities of socio-political and cultural pressures. Dr. Smith discusses how scientists should grapple with the current tension.

Episode Resources:

• Profile Page, Johns Hopkins Medicine
• Google Scholar Page
• Keynote Presentation: Immunogenomic Characterization of Tumor-Reactive TIL in Lung Cancers w/ Live Q&A
• Keynote Presentation: Characterizing the phenotype, function, and spatial interactions of tumor-reactive TIL

Connect & explore more: Visit The Life of Her Mind to listen, share, and access links and resources. Check out Labroots scholarship opportunities here. Submit a scientific poster to be featured in our event(s) here.

Dr. Stephanie Poindexter is a biological anthropologist at the University of Buffalo specializing in primatology. Doctor Poindexter conducts field, lab, and desk-based research into how primates use and navigate their habitats. More specifically, Doctor Poindexter investigates primate movement, morphology, and cognition. Of particular interest is the slow loris. Dr. Poindexter investigates how the environment, other animals, and their own cognitive and physical capacities influence the nocturnal slow loris's movement.

In this episode, we learn how Dr. Poindexter loved primates as a child, planned for medical school, then rediscovered and fell in love with primatology as an undergrad. We also learn how Dr. Poindexter came to specialize in the slow loris, and how she expands the scope of thinking about evolutionary drivers of movement and cognition.

Episode Resources:

• Faculty Page, University at Buffalo
• Check out Dr. Poindexter’s conservation work at Project Chimps

Stay up to date on the latest in science at ⁠Labroots.com⁠.

Kinesiology Professor Shilo Nelson’s story highlights the important point that there is no one correct way to approach a career in STEM.

Our conversation covers a range of topics, including the following:

• Prof. Nelson’s experience in the United States Air Force
• How Prof. Nelson parlayed her discipline and physical fitness into a stint as a Seattle Sea Hawks cheerleader;
• The importance of seeing – and taking – opportunities that don’t seem obvious fits with one’s background;
• How Prof. Nelson’s path as a kinesiology major at Eastern Washington University led to body building, work as an aerobics instructor, goat yoga, and more!

Stay up to date on the latest in science at ⁠Labroots.com⁠.

Tomi Akingbade is the founder of the Black Women in Science Network and a Ph.D. student in Neurochemistry at the University of Cambridge. Tomi’s scientific research centers on the inflammatory mechanisms of aggregates in Alzheimer’s disease. Interested in science since childhood, Tomi founded the Black Women in Science Network as a response to the lack of frank conversations about being a Black woman in science, and the supportive community such conversations generate. The image of what it is to be a scientist is changing, and must continue to do so, if the sciences are to achieve a comprehensive understanding of nature. Partly to that end, Tomi is working to expand the Black Women in Science Network into a global organization.

Cambridge University neurochemistry Ph.D. student, Tomi Akingbade is founder of the Black Women in Science Network. Tomi’s scientific research centers on the inflammatory mechanisms of aggregates in Alzheimer’s disease.

Our conversation covered a range of topics, including the following:

• How Tomi discovered neuroscience early in high school, but didn’t study in the field until years later because she didn’t know it was a career path
• The trials and tribulations of finding your way to – and through – a Ph.D. program, and the importance of supportive mentors throughout
• How Tomi started work in a virology lab in February 2020 – just before the COVID pandemic started
• How Tomi decided to start the Black Women in Science networking group in 2018

Episode Resources:

• Tomi Akingbade on LinkedIn
• Black Women in Science Network

Stay up to date on the latest in science at ⁠Labroots.com⁠.

Groundbreaking neurobiologist, Dr. Gina Turrigiano heads up the Turrigiano Lab in Brandeis University’s Biology Department. Dr. Turrigiano’s work focuses on brain plasticity. Our conversation covered a wide range of topics, including the following:

• How Dr. Turrigiano and her husband, electrophysiologist, Dr. Sasha Nelson, navigated the challenges involved in couples hiring at research institutions – especially when young children are in the mix;

• How Dr. Turrigiano’s undergraduate career as a biology major at Reed College led to a concentration in neurobiology;

• What “brain plasticity” means and how it applies to Dr. Turrigiano’s work;

• What homeostatic plasticity mechanisms are;

• Why Dr. Turrigiano thinks science is fun; and

• What Dr. Turrigiano’s life is like outside the lab.

Dr. Gina Turrigiano is the Joseph Levitan Professor of Vision Science in the Biology Department at Brandeis University, where she heads the Turrigiano Lab.

Dr. Turrigiano completed her undergraduate studies at Reed College, and her PhD at the University of California, San Diego, before moving to Massachusetts for her post-doctoral work at Brandeis. Publishing on a variety of topics in neuroscience since 1997, Dr. Turrigiano has long focused her research on brain plasticity. Recent research furthers the understanding of homeostatic plasticity mechanisms through studying sleep-wake cycles, and the results of her research include advancements in understanding how so-called self-tuning mechanisms relate to brain disorders like epilepsy and autism.

Dr. Turrigiano’s work has been recognized with fellowships from the MacArthur foundation and Sloan foundation, and awards from the McKnight foundation, the National Institutes of Health, and the Human Frontier Science Program Organization. A member of the American Academy of Arts and Sciences and National Academy of Sciences, a Fellow of the American Association for the Advancement of Science, and the President of the Society of Neuroscience, Dr. Turrigiano is a groundbreaking researcher working at the leading edge of neuroscience.

Episode Resources:

• Brandeis University Faculty

• Turrigiano Lab on Twitter/X

• 
  

Stay up to date on the latest in science at ⁠Labroots.com⁠

Dr. Daphna Joel is Professor of Psychology and Neuroscience at Tel Aviv University. Dr. Joel is a member of the School of Psychological Sciences and the Sagol School of Neuroscience.

After having completed her PhD in Psychobiology at Tel Aviv University in 1998, Dr. Joel received the Alon Fellowship for Young Scientists and then joined Tel Aviv University’s faculty. Dr. Joel’s work focuses on the relations between sex, gender, and brain structure and function. She has published over 70 papers and is the author of Gender Mosaic: Beyond the Myth of the Male and Female Brain. One of Dr. Joel’s central findings is that there is no “male” or “female” brain. Instead, each brain is a unique “mosaic” (combination) of features — some features may be more common in males, others in females, and others still common in both. Similarly, each individual possesses a unique mosaic of gender characteristics, such as behaviors, personality traits, and cognitive abilities.

More generally, Dr. Joel’s research reveals that even though biological sex is not an illusion, our binary conceptualization of sex, brain, and gender is illusory.

Learn More about the Gender Mosaic Project and fill out the Questionnaire here: https://gendermosaic.tau.ac.il/

Episode Resources:

• The Gender Mosaic Project Questionnaire
• Biography - Dr. Daphna Joel
• X - @DaphnaJoel
• Wikipedia - Dr. Daphna Joel

Stay up to date on the latest in science at ⁠Labroots.com⁠