In this episode of The Lead, host Cinzia Monaco, MD, PhD, is joined by Kinan Kneizeh, MD, and Konstantinos Vlachos, MD, PhD, to discuss "Pulsed Field Ablation Versus Sham to Treat Atrial Fibrillation: The PFA-SHAM Randomized Clinical Trial." The panel examines the trial's sham-controlled evidence for the effects of pulsed field ablation on atrial fibrillation recurrence, quality of life, AF burden, and psychological well-being, while considering placebo effects, study limitations, and the applicability of the findings to clinical practice.

Learning Objectives:
1. Describe the design, patient population, endpoints, and key findings of the PFA-SHAM randomized clinical trial.
2. Evaluate the effects of pulsed field ablation compared with a sham procedure on atrial fibrillation recurrence, AF burden, quality of life, and psychological well-being.
3. Assess the trial's limitations, potential placebo effects, and applicability to the management of patients with symptomatic atrial fibrillation.

Host: Cinzia Monaco, MD, PhD

Guests: Kinan Kneizeh, MD and Konstantinos Vlachos, MD, PhD

Disclosures:

C. Monaco
• No relevant disclosures

K. Kneizeh
• No relevant disclosures

K. Vlachos, MD, PhD
• No relevant disclosures

In this episode of The Lead, host Deep Chandh Raja, MBBS, MD, PhD, FHRS, is joined by Kars Neven, MD, PhD, and David Chieng, MBBS, CCDS, to discuss the journal article, Radiofrequency Ablation Produces Stiffer Atrial Lesions Than Pulse Field Ablation: In vivo and ex vivo magnetic resonance elastography in pigs. Together, they discuss the study's comparison of atrial lesions produced by radiofrequency ablation and pulse field ablation using in vivo and ex vivo magnetic resonance elastography in pigs.

Learning Objectives

• Review the study's comparison of atrial lesions produced by radiofrequency ablation and pulse field ablation.
• Discuss the use of in vivo and ex vivo magnetic resonance elastography to evaluate atrial lesions in pigs.
• Examine the differences in atrial lesion stiffness observed following radiofrequency and pulse field ablation.

Host: Deep Chandh Raja, MBBS, MD, PhD, FHRS

Guests: Kars Neven, MD, PhD and David Chieng, MBBS, CCDS

Disclosures:

D. Raja

• No relevant disclosures

K. Neven

• Honoraria/Speaking/Consulting Fee: Boston Scientific, Biosense Webster, Inc., Lifetech Scientific
• Stock Options-Privately Held: Field Medical

D. Chieng

• No relevant disclosures

Description:

In this episode of The Lead, host Jenelle Dziano, PhD candidate, is joined by Roopinder Sandu, MD, MPH, FHRS and Louise Segan, MBBS, MPH, PhD to discuss the journal article, Weight Loss in Older Patients With Persistent Atrial Fibrillation, The LOSE-AF Randomized Clinical Trial. Together, they review the findings of the LOSE-AF randomized clinical trial examining weight loss in older patients with persistent atrial fibrillation.

Learning Objectives

• Review the key findings of the LOSE-AF randomized clinical trial examining weight loss in older patients with persistent atrial fibrillation.
• Discuss the role of weight loss in the management of older patients with persistent atrial fibrillation.
• Examine the clinical implications of the study findings for patients with persistent atrial fibrillation.

Host: Jenelle Dziano, PhD candidate

Guests: Roopinder Sandu, MD, MPH, FHRS and Louise Segan, MBBS, MPH, PhD

Disclosures:

J. Dziano

• No relevant disclosures

R. Sandu

• No relevant disclosures

L. Segan

• No relevant disclosures