In this episode of The Holistic GLP-1 Podcast, Elizabeth sits down with McCall McPherson, PA—founder of Modern Thyroid Clinic and Modern Weight Loss—for a conversation that completely reframes what GLP-1 therapies actually do for the body.

McCall explains why GLP-1s may be one of the most important medical breakthroughs of our time—not simply because of weight loss, but because of their powerful impact on inflammation, metabolism, hormones, chronic disease and even longevity. Together, they explore how GLP-1s affect thyroid health, insulin and leptin resistance, cardiovascular risk, autoimmune conditions, muscle preservation and more!

They also unpack why standard dosing often causes unnecessary side effects, how micro-dosing changes outcomes, and how to use GLP-1s as a true healing tool—not a quick fix. If you want to understand the future of metabolic health, this episode is a must-listen.

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SHOW NOTES

[ 00:00 ] Introduction

[ 03:00 ] The Big Claim: "GLP-1s Will Change Medicine Forever"

[ 06:00 ] Inflammation: The Root Cause GLP-1s Quiet

[ 09:00 ] Why Thyroid Patients Are Seeing Breakthrough Results

[ 12:00 ] The 10–14% Lower Mortality Statistic

[ 15:00 ] The Danger of Standardized Dosing

[ 18:00 ] Red Flags That a Dose Is Too High

[ 21:00 ] Ozempic Face, Muscle Loss & Hair Loss — What's Really Going On

[ 24:00 ] How to Protect Hair, Skin & Muscle While on GLP-1s

[ 27:00 ] Why Overprescribing Happens

[ 30:00 ] Can You Come Off GLP-1s Successfully?

[ 33:00 ] The Thyroid Story Medicine Keeps Missing

[ 36:00 ] The Black Box Warning Explained

[ 39:00 ] Do GLP-1s Stop Working Over Time?

[ 42:00 ] How to "Reboot" Responsiveness

[ 45:00 ] Why Lifestyle Is the Missing Piece

[ 48:00 ] The Future of GLP-1s in Medicine

[ 51:00 ] McCall's Personal Journey

[ 54:00 ] What's Next for McCall

[ 57:00 ] Closing Thoughts

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🔗 Mentioned in This Episode:

Learn how to activate GLP-1 naturally and silence cravings!

CLICK HERE TO GET ⇒ Free Masterclass: Freedom From Food Noise: https://go.elizabethmcgann.com/start

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Get Connected with Elizabeth McGann:

Coaching Website: http://www.ElizabethMcGann.com

Instagram: http://www.instagram.com/elizabethmcgann

Facebook: https://www.facebook.com/ElizabethMcGannWellness

LinkedIn: https://www.linkedin.com/in/elizabethmcgann

X/Twitter: https://twitter.com/ElizabethMcGann

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Learn more about McCall McPherson PA-C:

Website: https://www.mccallmcpherson.com/

Instagram: https://www.instagram.com/mccallmcphersonpa/?hl=en

What if I told you that the side effects of nausea, constipation, muscle loss AND burnout on GLP-1s are not inevitable? That in many cases, they're simply a sign the medication is being used the wrong way?

In this week's episode of The Holistic GLP-1 Podcast, I sit down with Dr. Matthea Rentea—a double board-certified obesity medicine physician who is quietly revolutionizing how GLP-1s are used in clinical practice. This is one of the most nuanced, compassionate and empowering conversations we've had about how using GLP-1 medications can be part of a true healing journey—not a crash-and-burn weight loss strategy.

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SHOW NOTES

[ 00:00 ] Introduction

[ 01:20 ] How GLP-1s Changed Obesity Medicine

[ 05:05 ] Why Dr. Rentea Practices Holistic Medicine

[ 06:45 ] Dosing Strategy: Why The "Lowest Effective Dose" Works Best

[ 10:00 ] Carbohydrates, Insulin Resistance & Food Ordering

[ 13:40 ] How to Identify Insulin Resistance Early

[ 16:50 ] Why Side Effects Are Often Preventable

[ 18:40 ] Protein, Fiber & Protecting Muscle and Longevity

[ 22:20 ] Lean Mass vs. Skeletal Muscle Mass

[ 25:20 ] Bone Health, Strength Training & Aging

[ 28:30 ] Mindset, Identity & Behavior Change

[ 33:10 ] Dr. Rentea's Personal Weight Journey

[ 36:20 ] Are GLP-1s Lifelong?

[ 41:00 ] Can You "Re-sensitize" to GLP-1s?

[ 45:10 ] Genetics, Satiety Signaling & Healing Shame

[ 50:30 ] Supplements on a GLP-1 Journey

[ 54:50 ] What Real Success Looks Like on GLP-1s

***

🔗 Mentioned in This Episode:

CLICK HERE TO GET ⇒ Free Masterclass: Freedom From Food Noise: https://go.elizabethmcgann.com/start

***

Get Connected with Elizabeth McGann:

Coaching Website: http://www.ElizabethMcGann.com

Instagram: http://www.instagram.com/elizabethmcgann

Facebook: https://www.facebook.com/ElizabethMcGannWellness

LinkedIn: https://www.linkedin.com/in/elizabethmcgann

X/Twitter: https://twitter.com/ElizabethMcGann

***

Learn more about Dr. Matthea Rentea:

Website: https://www.renteaclinic.com/

Instagram: https://www.instagram.com/matthearenteamd/?hl=en

Why is it that nearly every woman hitting a GLP-1 weight-loss plateau thinks she needs more medication? And what if the real solution is actually… more metabolic health?

I hear this all the time when I'm coaching clients inside our Finally F**king Free program. And the truth is—your body isn't failing you. It's signaling it needs deeper support.

That's why I brought on today's guest, Dr. Dean Jones. He's a holistic obesity specialist who understands metabolic repair because he's lived this journey himself. And what I love is how aligned his philosophy is with what we teach here—using GLP-1s as a tool, not a crutch.

Today we're diving into what actually causes plateaus, how to get unstuck without starving or losing muscle, and why lower doses combined with a holistic approach create the most sustainable transformation.

So let's get into it!

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SHOW NOTES

[ 00:00 ] Introduction

[ 02:05 ] Meet Dr. Dean Jones

[ 04:35 ] Emotional Eating, Food Noise & GLP-1s

[ 06:40 ] Fasting Before GLP-1s

[ 09:40 ] Discovering Intermittent & Extended Fasting

[ 10:40 ] Using GLP-1s for Maintenance (Not Dependence)

[ 11:00 ] The FLOA Method: "Fasting Like Our Ancestors"

[ 12:20 ] Muscle Loss, GLP-1s & Fasting Myths

[ 14:10 ] Weekly Therapeutic Fasting Explained

[ 16:30 ] Why GLP-1s "Stop Working"

[ 17:05 ] Are Most People Using GLP-1s Wrong?

[ 19:05 ] Metabolic Health > More Medication

[ 20:35 ] What You Can Do Today

[ 22:10 ] The Metabolic Reset Phase

[ 22:40 ] How Many Calories Are "Right" on GLP-1s?

[ 26:15 ] Relearning Hunger Without Fear

[ 28:30 ] The Mindset Behind Sustainable Weight Loss

[ 31:20 ] Complementary Peptides & GLP-1s

[ 35:30 ] Why Lower GLP-1 Doses Are a Strategic Advantage

[ 39:40 ] Coaching, Accountability & Long-Term Success

[ 42:10 ] What Dr. Jones Is Most Excited About Next

[ 44:15 ] Final Reflections & Closing

***

🔗 Mentioned in This Episode:

Learn how to activate GLP-1 naturally and silence cravings!

CLICK HERE TO GET ⇒ Free Masterclass: Freedom From Food Noise: https://go.elizabethmcgann.com/start

***

Get Connected with Elizabeth McGann:

Coaching Website: http://www.ElizabethMcGann.com

Instagram: http://www.instagram.com/elizabethmcgann

Facebook: https://www.facebook.com/ElizabethMcGannWellness

LinkedIn: https://www.linkedin.com/in/elizabethmcgann

X/Twitter: https://twitter.com/ElizabethMcGann

***

Learn more about Dr. Dean Jones:

Website: https://coloradomedicalsolutions.com/about-us/

YouTube: https://www.youtube.com/@DrJonesDC