In this episode of The GLP-1 Podcast Show, I speak with Dr. Caroline Apovian, Professor of Medicine at Harvard Medical School and Co Director of the Center for Weight Management and Wellness at Brigham and Women’s Hospital, about the evolution of obesity treatment. We discuss why obesity is a chronic disease, how GLP-1 based therapies have changed clinical outcomes, and how they compare with lifestyle intervention and metabolic surgery. Dr. Apovian also addresses stigma, access barriers, and the risks of cosmetic use. Listen now on all major platforms!

"Stigma surrounding obesity has forced clinicians to repeatedly prove that treating obesity also prevents cardiovascular disease and diabetes."

Meet the guest: Dr. Caroline Apovian is Professor of Medicine at Harvard Medical School and Co Director of the Center for Weight Management and Wellness at Brigham and Women’s Hospital. A founding leader in obesity medicine, her research focuses on adipose tissue inflammation, cardiovascular risk, metabolic surgery, and pharmacotherapy for obesity.

What you will learn:

• (00:00) Highlight
• (01:23) Introduction
• (04:41) GLP-1 overview
• (07:55) Obesity disease model
• (13:35) Treatment comparisons
• (19:59) Cardiovascular outcomes
• (25:44) Cosmetic use debate
• (33:22) Final Questions

𝗟𝗶𝘀𝘁𝗲𝗻 𝗼𝗻 𝗔𝗽𝗽𝗹𝗲 𝗣𝗼𝗱𝗰𝗮𝘀𝘁𝘀, 𝗦𝗽𝗼𝘁𝗶𝗳𝘆 𝗼𝗿 𝗮𝗻𝘆 𝗺𝗮𝗷𝗼𝗿 𝗽𝗹𝗮𝘁𝗳𝗼𝗿𝗺.

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In this episode of The GLP-1 Podcast Show, I speak with Melissa Mitri, Registered Dietitian and weight loss expert at Melissa Mitri Nutrition, about real-world nutrition strategies for patients using GLP-1 therapies. She focuses on nutrient density, meal structure, side effect management, muscle preservation, and long-term habit building. Melissa shares clinical insights from nearly two decades of practice working directly with patients. Melissa highlights how nutrition and lifestyle optimize outcomes alongside GLP-1 medications. Listen now on all major platforms!

“GLP-1 therapies shift nutrition counseling away from calorie obsession toward nutrient density, because patients eat smaller portions and every bite must support metabolic health.”

Meet the guest: Melissa Mitri, MS, RD, is a Registered Dietitian, weight loss expert, and founder of Melissa Mitri Nutrition. She specializes in sustainable weight management, including nutrition support for patients using GLP-1 therapies. With nearly 20 years of clinical experience, her work focuses on nutrient density, habit formation, and evidence based care.

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GLP-1 Cheat Sheet for Clinicians

What you will learn:

• (00:00) Highlight
• (00:45) Introduction
• (02:27) Nutrition approach
• (04:59) Meal timing
• (07:23) Side effects
• (12:14) Muscle preservation
• (17:35) Long-term habits
• (29:49) Final Questions

𝗟𝗶𝘀𝘁𝗲𝗻 𝗼𝗻 𝗔𝗽𝗽𝗹𝗲 𝗣𝗼𝗱𝗰𝗮𝘀𝘁𝘀, 𝗦𝗽𝗼𝘁𝗶𝗳𝘆 𝗼𝗿 𝗮𝗻𝘆 𝗺𝗮𝗷𝗼𝗿 𝗽𝗹𝗮𝘁𝗳𝗼𝗿𝗺.

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In this episode of The GLP-1 Podcast Show, I speak with Dr. Ken Fujioka, Clinical Professor of Medicine and Director of the Nutrition and Metabolic Research Center at Scripps Clinic, about the clinical evolution of GLP-1-based therapies. He covers next-generation dual and triple agonists, dose titration, nausea management, and long-term weight maintenance. Dr. Fujioka also examines oral alternatives, safety concerns, and real-world prescribing considerations. Listen now on all major podcast platforms!

"Combining multiple satiety hormones allows greater weight reduction by targeting complementary brain and gastrointestinal pathways involved in appetite regulation."

Meet the guest: Dr. Ken Fujioka is a Clinical Professor of Medicine and Director of the Nutrition and Metabolic Research Center at Scripps Clinic, specializing in obesity, diabetes, and metabolic disease management. His work focuses on clinical trials, patient-centered weight treatment, and GLP-1-based therapies.

What you will learn:

• (00:00) Highlight
• (00:57) Introduction
• (02:59) New GLP-1 agents
• (05:12) Dose titration
• (08:14) Glucagon role
• (10:29) Clinical precautions
• (12:53) Oral alternatives
• (22:42) Final Questions

𝗟𝗶𝘀𝘁𝗲𝗻 𝗼𝗻 𝗔𝗽𝗽𝗹𝗲 𝗣𝗼𝗱𝗰𝗮𝘀𝘁𝘀, 𝗦𝗽𝗼𝘁𝗶𝗳𝘆 𝗼𝗿 𝗮𝗻𝘆 𝗺𝗮𝗷𝗼𝗿 𝗽𝗹𝗮𝘁𝗳𝗼𝗿𝗺.

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LinkedIn: The GLP-1 Podcast Show