In this episode, Dr. Bonnie Kaplan shares a statistic that should stop everyone in their tracks: 50% of people will be diagnosed with a mental disorder at some point in their lifetime. When she was a kid in the 1950s, that rate was 1% or less.

As a professor emeritus at the University of Calgary and co-author of The Better Brain, Dr. Kaplan has spent decades researching what went wrong. She shares the case of "Andrew," a 10-year-old with childhood psychosis who recovered on micronutrients when six months of psychiatric care failed…yet his doctor refused to try it with other patients because "it's not part of clinical practice guidelines."

This episode was initially released in July 2022

This interview took place on a historic day: the FDA removed the black box warning for HRT (hormone replacement therapy) after 20 years. My guest, Dr. Mariza Snyder, author of The Perimenopause Revolution, explains why this matters and why women have been suffering needlessly for decades while doctors dismissed their symptoms as "just aging" or "just stress."

Perimenopause is the 4 to 10-year transition where hormones wildly fluctuate before menopause, and Dr. Snyder calls it "the window of vulnerability." She uses a powerful metaphor: imagine estrogen as your brain's master CEO who shows up like clockwork from 9 AM to 6 PM for 30 years.

Then, suddenly, without warning, it shows up at 2 PM one day and leaves at 11 PM, then shows up at 6 AM the next day and leaves at 11 AM. Your brain scrambles trying to regulate energy, neurotransmitters, sleep, mood, and cravings.

The most compelling insight of our conversation is a Mayo Clinic study that found 84% of menopausal women don't seek care. Why? Because they feel judged in the doctor's office.

Dr. Snyder wrote her book as the roadmap she desperately needed when she started her own perimenopause journey, connecting symptoms to future health outcomes and providing practical solutions beyond just "you're getting older."

In this episode with Dr. John Lieurance, he drops a bombshell in the first few minutes: "I take hundreds of milligrams [of melatonin] every night, and I've gone through months and months of taking it religiously."

While most melatonin supplements contain a dose of 0.3 to 3 milligrams, Dr. Lieurance has 30 years of clinical experience and, during our conversation, shares his unorthodox but largely research-backed views on melatonin, methylene blue, and mitochondrial health.

As one of the world's leading clinical experts on melatonin and methylene blue, Dr. Lieurance reveals findings that most people have never heard, including why melatonin is an amazing adaptogen and how it even prevents the Warburg effect that powers cancer cells.

The second half of our conversation explores methylene blue, the original compound that inspired the term "magic bullet." Dr. Lieurance explains how this brilliant blue salt was discovered while searching for a malaria cure, how it increases mitochondrial function by an average of 30%, and why it acts as both a prooxidant and antioxidant.

Most fascinating is the synergy with red light therapy…methylene blue absorbs 660-nanometer photons, supports cytochrome C oxidase, and creates powerful antimicrobial effects. He shares clinical dosing protocols, debunks FDA warnings, and explains why higher doses are more effective than the micro-doses commonly recommended.

In this podcast, Dr. Lieurance and I discuss:

• His personal health journey and why he takes hundreds of milligrams of melatonin every night, while maintaining high testosterone levels, directly contradicting Andrew Huberman's warnings based on flawed rodent studies

• Melatonin studies that used up to 150,000 milligrams with zero toxicity found, yet recent claims suggest melatonin is toxic to kids, with little research to support it

• The fact that your gut produces 400 times more melatonin than the pineal gland!

• Every single cell produces its own melatonin within the mitochondria, a discovery that only emerged in the last couple years, completely reframing melatonin's importance

• The biological reason why you can take large amounts of melatonin for extended periods and stop the next day without suppression of natural production

• The connection between melatonin, hormesis, and your mitochondria

• How high-dose melatonin protects you from sun damage

• The interesting story of methylene blue, the original "magic bullet" discovered while curing malaria

• How methylene blue increases mitochondrial function by 30% on average