Dr. Jeremy Koenig sits down with Dr. Andrew Brandeis, CMO and co-founder of OK Capsule, for a wide-ranging conversation about the real reason personalized supplements fail: it's not the science, it's the logistics. Andrew shares his journey from naturopathic physician working alongside MDs in San Francisco urgent care to building a manufacturing-as-a-service platform that pre-sorts and drop-ships personalized daily vitamin packets for supplement brands worldwide. The two dig into supplement quality scandals, the psychology of adherence, and how AI — specifically Claude — is quietly becoming a diagnostic thought partner for both doctors and patients. Andrew even tells the story of how an AI chat uncovered the real root cause of his decade-plus psoriasis flare-ups after dermatologists came up empty. The episode closes with a look at OK Capsule's new MCP integration (basically an AI-native API that turns weeks-long tech integrations into a single click), plus a teaser for Andrew's upcoming satirical novel on how blockbuster drugs actually get made — through marketing, not medicine.

Key Takeaways

• 💊 Supplements only work if three things line up: the right formula for the right condition, verified label-accurate quality, and actual consistent adherence — most plans fail on that third one
• 🏭 OK Capsule isn't a supplement brand — it's an API/MCP-driven platform that lets other supplement brands offer personalized, private-labeled daily packs at scale
• 📉 Independent testing has repeatedly found a shocking number of Amazon supplement products don't actually match their label claims — brand trust exists for a reason
• 🤖 AI tools like Claude are becoming a "second opinion" layer for both patients and physicians — pulling years of labs, wearables, and raw genetic data into one context window no human doctor could hold in their head
• 🧬 Andrew's real-life psoriasis case: 15 years of dermatologists saying "it's genetic, here's a steroid cream" — until an AI-assisted deep dive into his raw 23andMe data flagged a specific immune overreaction to a common skin yeast, and treating that actually resolved it
• 🔌 MCP (Model Context Protocol) is being called "the new API" — reducing what used to be weeks of engineering integration work down to a single click for AI-to-AI systems
• 📊 Function Health and its wave of copycats nailed the "here are your results" part of personalization — but most stop short of actually delivering a physical product or solution, which is the gap OK Capsule fills
• 👨‍👩‍👧 A fascinating tangent on where this is all headed: "family LLMs" that hold context across a household's health history, habits, and dinner-table conversations
• 📚 Andrew's satirical novel Pillars: Science and Other Profitable Lies (out early 2027) pulls back the curtain on how pharmaceutical "blockbusters" are really built — through marketing narratives, not necessarily medical superiority
• 🎯 Big picture theme: stop waiting for better information and start building better infrastructure — make the healthy choice the easy choice, and behavior change follows automatically

Chapters List:
00:47 Transitioning Roles: From CEO to CMO
05:50 The Journey to OK Capsule: Foundational Insights
09:34 Building a Platform for Personalized Supplements
13:04 Navigating Quality and Compliance in Supplements
16:06 AI in Healthcare: Opportunities and Challenges
19:00 The Rise of Personalized Health Solutions
21:30 Innovations in AI and Health Integration
25:29 The Impact of MCP on Health Management
28:47 Personalized Supplements and Health Outcomes
32:40 AI as an Augmentation Tool for Doctors
39:02 The Future of Personalized Health and Family Dynamics
41:41 Closing Thoughts and Future Directions

LINKS:

https://www.drjeremykoenig.com/
https://www.instagram.com/drjeremykoenig/
https://www.youtube.com/@drjeremykoenig

Here's the link for this week's episode: https://drjeremykoenig.substack.com/.

Chris Burres has spent over three decades chasing a molecule most people have never heard of, and the story behind it sounds almost too wild to be true. In 2012, a French toxicity study accidentally discovered that Carbon 60 (ESS60) extended rat lifespans by 90%, making it one of the longest mammalian longevity results ever recorded in peer-reviewed research. On this episode of The DNA of Things, Dr. Jeremy Koenig sits down with Burres, co-founder of SES Research and founder of My Vital C, to unpack the science of oxidative stress, mitochondrial health, and his own BOSS Theory (Buffering Oxidative Stress System). From the Nobel Prize-winning discovery of the molecule at Rice University to real-world testimonials on sleep, energy, and mental focus, this conversation dives deep into carbon nanomaterials, biohacking, and what it actually takes to buffer aging at the cellular level.

Key Takeaways

🧬 The 90% Longevity Study — How a 2012 French toxicity study on Carbon 60 accidentally became one of the longest-recorded lifespan extensions in mammal history

⚗️ From Nobel Prize to Supplement Shelf — The 1985 Rice University discovery of the C60 molecule and its 11-year path to a Nobel Prize in Chemistry

🔋 Mitochondria & Oxidative Stress, Explained — Chris breaks down the BOSS Theory (Buffering Oxidative Stress System) using his now-famous Mardi Gras/bumper cars analogy

😴 The Sleep-Energy Connection — Why the most consistent testimonial from ESS60 users is better focus and energy during the day paired with deeper sleep at night

🧪 The Messy Supplement Industry — Why Chris resisted entering the supplement space for years, and what finally changed his mind

💊 Real Protocols & Dosing — Olive oil vs. avocado oil vs. MCT oil, and how Chris personally stacks his morning routine

📊 What's Next: Ongoing Research — Upcoming studies on headaches, HS-CRP inflammation markers, sleep, and skin aging

🎁 Free Resources for Listeners — Chris shares an 18-tip biohacking guide from his Longevity Summit interviews with 57 experts, plus an exclusive discount link

LINKS:

https://www.drjeremykoenig.com/
https://www.instagram.com/drjeremykoenig/
https://www.youtube.com/@drjeremykoenig

Here's the link for this week's episode: https://drjeremykoenig.substack.com/.

Jeremy Malecha spent his career building cloud-connected medical devices at ResMed before functional medicine pulled him in through the side door — literally, as his wife's first patient. What he found was a mess: lab results in one place, wearable data in another, supplement protocols scribbled into a Word doc, and zero way to connect any of it. That frustration became Biocanic, a platform now used by thousands of practitioners and over 270,000 patients to turn raw biomarker data, wearable streams, and intake forms into structured, repeatable protocols. In this conversation, Jeremy and Dr. Jeremy Koenig dig into why functional medicine is data-rich but action-poor, how AI changed the speed of building personalized care tools almost overnight, why "death by five-minute paper cuts" is quietly burning out practitioners, and what it actually takes to scale individualized health without losing the personalization that makes it work. They also get into the bigger shift happening post-pandemic — from "doctor knows best" to "I'm responsible for my own health" — and why that shift, not better algorithms, is what's actually going to disrupt healthcare.

Key Takeaways:

🧬 How Biocanic turns scattered labs, wearables, and intake data into one trackable health record
⏱️ Why "death by five-minute paper cuts" is the real bottleneck stopping practitioners from scaling
🤖 What changed for health tech builders once AI tools caught up to what Jeremy was doing back in 2018
📊 Why functional medicine is data-rich but action-poor — and what closes that gap
🔁 How practitioners build repeatable protocols without sacrificing personalized care
💍 Using wearables (Aura, Whoop, Garmin) and self-experimentation to catch health shifts before they become problems
🩺 The difference between functional medicine patients, health optimizers, and longevity biohackers — and why practitioners serve them differently
🏥 Why healthcare disruption is coming from outside the system, not from insurance or hospitals
🧠 The "teach a person to fish" philosophy behind personalized health coaching
❤️ Why the real metric of long-term health might be relationships, not biomarkers

LINKS:

https://www.drjeremykoenig.com/
https://www.instagram.com/drjeremykoenig/
https://www.youtube.com/@drjeremykoenig

Here's the link for this week's episode: https://drjeremykoenig.substack.com/.