The Antidepressant That Vomited Its Way Toward Being a Psychedelic
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The Antidepressant That Vomited Its Way Toward Being a Psychedelic
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著者：
A forgotten drug from 1966 behaved like a true psychedelic in animals yet produced projectile vomiting in monkeys and severe gastrointestinal distress in humans at 25 mg - so how could the same molecule show LSD-like head-twitches and still fail to produce visions in people? What if a single receptor blockade could have unlocked its psychedelic effects?
In this episode, we trace the published record from the first syntheses through animal conditioning studies, receptor pharmacology, and halted human exposure to ask whether quipazine’s paradox could ever have been resolved and what remained unpublished in later work.
Person: Jerrold C. Winter
Date: 1966
Compound: quipazine (one-(two-quinolinyl)piperazine; 2-QP)
Dose reported in humans: 25 mg
Behavioral marker: head-twitch response in rodents and monkeys
- Quipazine was first described in the scientific literature in 1966.
- By 1971 researchers characterized quipazine as antidepressant-like in laboratory animals.
- In 1977 animal studies documented quipazine produced a head-twitch response similar to LSD, psilocybin, and mescaline.
- Human subjects given 25 mg reported nausea, flatulence, and severe gastrointestinal distress with no visions.
- Quipazine is a potent agonist at 5-HT3 (causing vomiting) but its psychedelic-like animal effects were mediated through 5-HT2A, blocked by ketanserin.
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