In drug discovery and development, every part of the process matters. Scientists learn from every experiment and every observation. In fact, some of the most cutting-edge advancements in medicine are being dreamed up from findings uncovered in the past.

In this episode, co-hosts Dr. Raven Baxter and Dr. Ronald Gamble dive deep into antibody drug conjugates, a groundbreaking modality that uses targeted antibody engineering to deliver potent chemotherapy directly to cancer-causing cells. They explore the complex ADC creation process and learn how ADCs are changing the standard of care for bladder cancer, from someone with a personal relationship to the disease.

Featured Guests:
– Renee Barron-Gores, Caregiver
– Phoenix Ho, Vice President, Oncology Early Clinical Development, Pfizer
– Sharsti Sandall, Executive Director, ADC Biology, Oncology Research Unit, Pfizer

Dive into the episode here:
1:16 - Old ideas yield new discoveries
3:01 - How do antibody drug conjugates work?
5:07 - The origins of ADCs
8:36 - ADCs allow for more targeted cancer treatment
10:44 - How are ADCs structured?
14:16 - How do scientists find the best ADC combinations?
18:27 - Developing oncology drugs
22:02 - ADCs and bladder cancer
24:28 - A caregiver’s perspective on cancer treatment
38:12 - Science Will Win

Season 5 of Science Will Win is created by Pfizer and hosted by Dr. Raven Baxter and Dr. Ronald Gamble. It’s produced by Acast Creative Studios.

Check out our social media platforms to take a deeper look into the labs and stories we discuss during the episodes: Instagram (@pfizerinc), TikTok (@pfizer)

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Protein-protein interactions facilitate numerous bodily processes – everything from the basics of how our muscles contract to the more complex ways cancer can spread through the body. So, what if there was a way to alter some of these interactions? Or even create new ones?

In this episode, we’re diving into the fascinating field of molecular glues, a revolutionary modality on the precipice of changing the treatment landscape for certain cancers and potentially other diseases and conditions.

Featured Guests:
– Joyann Donaldson, Principal Scientist, Synthesis Group Lead, Pfizer
– Jennifer LaFontaine, Head of Oncology Medicinal Chemistry, Pfizer
– Neal Sach, Research Fellow, Pfizer
– Jillian Spangler, Associate Research Fellow, Pfizer

Dive into the episode here:
0:50 - A metaphor to explain molecular glues
2:36 - How do molecular glues work in the body?
5:57 - A new frontier for cancer treatment
13:05 - The history behind molecular glues
16:59 - How do scientists design molecular glues?
19:05 - A visit to Pfizer’s La Jolla labs
32:42 - How can molecular glues change the patient experience?
36:42 - Molecular glues beyond cancer treatment

Season 5 of Science Will Win is created by Pfizer and hosted by Dr. Raven Baxter and Dr. Ronald Gamble. It’s produced by Acast Creative Studios.

Check out our social media platforms to take a deeper look into the labs and stories we discuss during the episodes: Instagram (@pfizerinc), TikTok (@pfizer)

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The next frontier of medicine is focused on highly targeted drug therapies that could expand the possibilities of individualized patient care. Today, scientists are working on a particular type of molecule that could harness multiple capabilities and treat inflammatory and autoimmune diseases in ways never done before.

In this episode, co-hosts Dr. Raven Baxter and Dr. Ronald Gamble explore how the latest advancements in antibody engineering led to multispecific antibodies—powerhouse molecules that can do the jobs of multiple drugs in one. They learn all about what it takes to assemble these antibodies and the impact they could make on patients—with a patient.

Featured Guests:
– Emma Guttman, Chair of the Department of Dermatology, Icahn School of Medicine at Mount Sinai
– Amanda Lopez, Patient, Texas Ambassador for the National Eczema Association
– Laird Bloom, Senior Director of Biomedicine Design, Pfizer
– Thomas Wynn, Vice President of Discovery, Inflammation & Immunology, Pfizer

Dive into the episode here:
1:12 - A metaphor for multispecific antibodies
4:08 - How do multispecific antibodies work?
10:39 - The history behind multispecific antibodies
16:29 - How are multispecific antibody drugs are made?
22:58 - An eczema expert on the potential of multispecific antibodies
29:30 - Amanda Lopez's eczema story
40:14 - What's next, and closing thoughts

Season 5 of Science Will Win is created by Pfizer and hosted by Dr. Raven Baxter and Dr. Ronald Gamble. It’s produced by Acast Creative Studios.

Check out our social media platforms to take a deeper look into the labs and stories we discuss during the episodes: Instagram (@pfizerinc), TikTok (@pfizer)

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.