Phototransduction Cascade
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Phototransduction Cascade
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Episode 47 – Phototransduction Cascade
Welcome back to Basic Sciences in Ophthalmology.
Hi my name is Dr Thomas Whitelaw and I am your host. In this episode, we explore one of the most elegant and important biochemical processes in vision: the phototransduction cascade.
Phototransduction is the mechanism by which light energy is converted into an electrical neural signal within the retina. This process occurs within the photoreceptors — rods and cones — and forms the foundation of visual perception.
The cascade involves highly coordinated molecular events including:
• Activation of visual pigments
• Intracellular signalling pathways
• Ion channel regulation
• Signal amplification
• Recovery and adaptation mechanisms
Understanding phototransduction is fundamental to retinal physiology and helps explain many inherited retinal disorders and degenerative diseases.
Today’s episode is divided into three sections:
1. Rhodopsin activation
2. The G-protein cascade
3. Signal amplification and recovery