Photobiomodulation in Ophthalmology: Mechanisms and Clinical Evidence
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Photobiomodulation in Ophthalmology: Mechanisms and Clinical Evidence
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Photobiomodulation, or PBM, uses low-level red and near-infrared light to influence cellular energy production. In ophthalmology, it's being studied most seriously for retinal conditions like dry age-related macular degeneration, where mitochondrial stress in the retina and RPE plays a central role. In this episode, Dr. Saikumar Gandapodi walks through the biology — how light interacts with cytochrome c oxidase, why the retina is uniquely metabolically demanding, and what recent human trials do and don't tell us.
We separate the established from the emerging at every turn. Dr. Gandapodi is candid about the limits: PBM is not a cure, dosing is still being worked out, and much of the mechanistic story comes from lab and animal models. He also explains how PBM fits into an integrative, whole-person framework at Netra Eye Institute — always as an adjunct to standard ophthalmic care, never a replacement.
This is a research-driven conversation for anyone curious about where light-based therapy is genuinely heading in eye medicine, and how to think critically about early but promising science.