When Bernadette joins the guys and Penny for their usual Chinese take-out dinner, Bernadette, the microbiologist, becomes fascinated with Leonard's physics project. Both Howard and Penny become a little jealous of this new friendship. Howard sees what Leonard is doing as the way he himself tries to pick up women, and as such wants Leonard to uninvite Bernadette to view his upcoming experiment. Penny, on the other hand, wants to bond more with Leonard by learning "a little physics" from Sheldon, who agrees if only because he can treat it as a scientific experiment. When Sheldon wants to go through 2,600 years of physics history, Penny may regret her choice of teacher.

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Yes everyone sickness has invaded the home.....Kat Is Sick !!!

After their third date, Bernadette wants an understanding with Howard about where their relationship is heading before proceeding to the next step of sex. Howard is unsure if Bernadette is the one for him as he always imagined ending up with a beautiful science fiction actress. One of his fantasy women, Katee Sackhoff, helps Howard figure out what he should do. But will Bernadette agree with his decision? Meanwhile, Sheldon is being interviewed by Ira Flatow on National Public Radio (NPR). While Sheldon is doing the live telephone interview from his office, Barry Kripke decides to have a little fun with Sheldon by tampering with his office's ventilation system, the resulting effect on Sheldon causing him some embarrassment with the listening audience. Leonard convinces Sheldon that he can get exact revenge on Kripke rather than hiding out and pouting, which is what Sheldon has been doing.

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While Leonard, Howard and Raj are off camping to observe the Leonid meteor shower, Sheldon is at home doing work. It's lucky for Penny that Sheldon did stay behind as she dislocated her shoulder when she slipped taking a shower. She is immobile in her bathtub. She yells loud enough for Sheldon to hear and for him to come help her. On Penny's pleas, Sheldon agrees to drive her to the emergency room, despite he only holding a learner's permit and never having driven an actual automobile. Will Sheldon do better behind the wheel of an actual car than he has on his driving simulator? Beyond the drive to and from the hospital, Penny asks Sheldon for a few special favors. Meanwhile back at the campsite, Leonard, Howard and Raj are feeling the effects of the special ingredient in the cookies they ate that were given to them by some hippie women.

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Justin, Penny's rock musician friend from Omaha, is coming to Los Angeles looking for work in the industry. Penny is letting him sleep on her couch for a few weeks. This offer doesn't sit well with a jealous Leonard, who learns that Justin and Penny did at one point "go out". Beyond the actual standoff between Leonard and Penny, their fight affects Howard and Raj, who take opposing sides, and Sheldon, who just doesn't like fights. As he feels this fighting is affecting him more than anybody else, Sheldon takes matters into his own hands. But will Sheldon end up hurting them and himself more than he helps?

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To chase after a woman with whom he had no chance - again - Howard leaves Raj at a critical moment during a kite flying challenge against Sheldon and Leonard. This is the last straw for Raj who sees himself as second priority behind Howard's quest for unattainable women. Will Howard be able to regain Raj's friendship? Meanwhile, Leonard learns that Penny has not invited him to a football game watching party at her apartment. He realizes that he has never met any of Penny's friends, which makes him think she's ashamed of him. She assures him that it is only because she feels he will be bored. But to fit in with Penny's friends, Leonard makes an effort to learn all about football by watching games and reading text books on the subject. Not quite grasping the whole football game watching culture, Leonard soon learns that someone unexpected in his own social circle knows all about football and may be able to teach him better than "Football for Dummies" can.

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Howard reminds Leonard of a five-year-old pact between the two. Effectively, the pact stipulates that Penny has to set Howard up with one of her friends. Leonard has to tread lightly to ask Penny for this favor. A reluctant Penny does find someone, but she may regret it when she and Leonard go on a double date with them. Meanwhile, Raj tries to talk Sheldon into entering a $500 top prize Mystic Warlords of Ka'a tournament with him to be held at the comic book shop. Sheldon has no interest in entering because, with his eidetic memory, the game is no challenge. Sheldon changes his mind when he learns that Wil Wheaton, number six on his arch enemy list (Wil didn't show up for a scheduled appearance at a sci-fi convention that Sheldon attended in 1995), has entered. Sheldon's goal is to crush 'Wesley Crusher'. During the tournament, can Wil do anything to change Sheldon's mind about him?

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It's Columbus Day and Thanksgiving is approaching, but Raj in particular is not in a thankful mood. His research stalled six months ago with no hope of success. With no job, his visa to stay in the United States becomes invalid which means that he will be deported back to India. Although Penny comes up with the obvious solution of Raj getting another job, jobs for astrophysicists are few and far between, with no guarantee of Raj even getting the job if there was one. With extra moneys just received from the university for his own research, Sheldon kind of offers Raj a job, but the nature of the offer is somewhat unclear, as would be Sheldon and Raj's working relationship. But a byproduct of Raj and Sheldon spending more time together is that Howard no longer has his best friend with who to hang out. So Howard decides to hang out with Leonard and Penny instead, who lose their much wanted alone time.

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