GLP-1 medications like Ozempic, Wegovy, Mounjaro, Zepbound, and semaglutide are everywhere—but what do they actually do in the body, who truly benefits from them, and where does nutrition fit in?

In part one of this two-part series, Cassie breaks down the science behind GLP-1 receptor agonists using evidence, not hype.

This episode explores:

• What GLP-1 medications and peptides are and how they work in the body
• Medical use vs. cosmetic or weight-loss-driven use
• How GLP-1s impact appetite, insulin, gastric emptying, and calorie intake
• Risks of muscle loss and potential bone density changes
• Why protein intake, fiber, resistance training, and overall nutrition are critical
• Lifestyle habits that support natural GLP-1 production
• What happens when people come off GLP-1 medications—and why weight regain and “food noise” aren’t willpower issues, but biology

Cassie also explains why GLP-1s are metabolic tools, not magic fixes, and how working with a dietitian before, during, and after these medications can protect muscle mass, support gut health, stabilize blood sugar, and create sustainable habits that last beyond the prescription.

If you’re considering GLP-1 medications, currently taking them, transitioning off, or wondering how to support your health naturally, this episode will help you make informed, compassionate, and science-based decisions—without fear, shame, or extremes.

👉 Don’t miss Part 2, where we dive deeper into food noise, body image, and the psychology behind GLP-1 use.

Chapters List:

00:00 Introduction to GLP-1 Medications

01:24 Understanding GLP-1 and Peptides

04:15 Who is Using GLP-1 Medications?

07:53 Mechanism of Action of GLP-1s

10:18 Weight Loss and Health Considerations

13:56 Nutritional Strategies for GLP-1 Users

18:58 Transitioning Off GLP-1s and Dietitian Support

23:23 Sustainable Health Beyond GLP-1s

Wellness That FIts

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References

Article in Lancet - lean muscle loss