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Oral vs Injection vs Cream: The Testosterone Showdown

Oral vs Injection vs Cream: The Testosterone Showdown

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Testosterone therapy is exploding in popularity, especially among midlife women — but how you take testosterone dramatically affects how it works in your body.

In this episode, Joanne breaks down the three major delivery systems — transdermal creams, oral lozenges, and injections — and explains why some women are now being told they’re “poor absorbers” and switched to oral or injectable forms.

You’ll learn:

  • Why women may not respond to topical testosterone (and why “poor absorber” is often misdiagnosed)

  • How creams differ from orals in absorption, side effects, and DHT conversion

  • Why oral lozenges feel strong quickly — and the real reason they spike DHT

  • Why injections seem aggressive but actually deliver the smoothest hormonal profile

  • Which delivery system works best depending on your goals, symptoms, and physiology

  • How men differ in absorption and why some men do brilliantly on gels while others might as well bathe in them

  • How dosing, metabolism, and estrogen/testosterone balance influence results

  • How to talk to your provider about choosing the right method

This episode is a must-listen for any woman navigating midlife hormones — and for men who want to understand why their therapy may or may not be working.

💉 Delivery Systems Explained

Joanne breaks down:

1. Transdermal Creams
  • Gentle, steady, least DHT-converting

  • Great for subtle libido, mood, strength improvements

  • Why absorption varies wildly between women

  • When creams are not enough

2. Oral Lozenges
  • Fast-acting, potent, and sharp

  • More likely to spike DHT

  • Why these are often a solution for “non-responders” — but come with caveats

  • The classic “love it or hate it” delivery method

3. Injections
  • The smoothest and most predictable system

  • Lowest DHT spikes compared to oral

  • Best for consistent energy, stable mood, and strong results

  • Why smaller, more frequent microdoses are often ideal for women

🔥 Who This Episode Is For
  • Women feeling under-dosed or inconsistent on testosterone cream

  • Women newly prescribed oral testosterone and unsure what to expect

  • Anyone concerned about androgenic symptoms like acne, hair shedding, or irritability

  • Men frustrated with gels or creams

  • Anyone navigating TRT/HRT and wanting real science without fear or fluff

👀 Want More Like This?

This episode is part of Joanne’s in-depth midlife education series. If you love detailed, physiology-first coaching — not surface-level soundbites — you’ll love what’s coming next.

🌐 Explore the New Website

My brand-new website is live (not fully finished, but go have a peek): 👉 www.joannelee.com

This is where all upcoming programs, courses, podcasts, and resources will live.

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