In this episode, our host, Dr. Scott Sperling, and student leader, Jared Jacoboson Cherry, meet with authors Dr. Kristina Gicas and Michelle Blumberg to discuss their recent paper, Examination of Objective and Subjective Cognition and Their Association With Functional Outcomes: A Cross-Sectional Study in a Canadian Sample of Homeless and Precariously Housed Adults. The authors share insights from their cross-sectional study of 88 community-dwelling adults experiencing homelessness or precarious housing, which examined the associations between facets of cognition and domains of quality of life and perceived everyday functioning. The conversation explores the importance of involving this population in clinical research and how subjective cognitive measures could be included alongside objective measures to obtain a more comprehensive understanding of the needs of homeless populations.

In this episode, our host, Dr. Scott Sperling, and student leader, Steven Harris, meet with authors Dr. Roee Holtzer and Andrew Fox to discuss their recent paper, Mediating Effect of Cognitive Reserve on Associations Between Processing Speed and Memory in Older Adults with and without Multiple Sclerosis. The authors share insights from their study of 104 older adults with MS and 105 healthy controls who underwent neuropsychological testing and brain magnetic resonance imaging. Using regression modeling to derive cognitive reserve, they found that cognitive reserve fully mediated the association between processing speed and immediate verbal recall, and partially mediated the association for delayed recall. The conversation explores how these findings highlight the protective role of cognitive reserve against memory decline in older adults, regardless of the presence of Multiple Sclerosis.

In this episode, our host, Dr. Scott Sperling, and student leader, Jared Jacoboson Cherry, meet with authors Sophie van der Landen and Dr. Sietske Sikkes to discuss their recent paper, "The relationship between cognitive domains and everyday functioning in Alzheimer's disease." The authors share insights from their study of over 600 participants with biomarker-confirmed Alzheimer's disease, ranging from subjective cognitive decline to dementia. Using advanced statistical modeling, they found that difficulties in memory, visual attention, mental flexibility, and visuoconstruction were closely linked to challenges in daily activities, while other cognitive domains like working memory, shifting, fluency, and inhibition, and naming were not. The conversation explores how these findings could shape more personalized care strategies and improve outcomes in clinical trials for Alzheimer's disease.

In this episode of Meet the Authors, Dr. Scott Sperling is joined by first author Dr. Brandon Gavett to discuss his paper, Domain-Specific Changes in Everyday Cognition: Associations with Diagnosis Change and Gray Matter Volume Change. Drawing on longitudinal data from 891 older adults, the study examines how cognitive abilities change over time and how these changes relate to diagnostic transitions and brain atrophy. Findings highlight the sensitivity of the Everyday Cognition (ECog) scale to clinical disease severity and underlying gray matter atrophy when used longitudinally.

In this episode, Dr. Scott Sperling discusses the article Inhibitory Control Underpins the Relationship Between Cognitive and Psychological Inflexibility After a Moderate to Severe Traumatic Brain Injury with authors Drs. Diane Whiting and Josh Faulkner. This study examined how deficits in cognitive flexibility relate to psychological inflexibility and distress among individuals with a traumatic brain injury (N = 66). Results showed that poorer performance on the Stroop color-word task, a measure of inhibitory control, was significantly associated with greater psychological inflexibility and distress. Overall, findings support the idea that cognitive flexibility—particularly inhibitory control—is a key component of psychological inflexibility.

In this episode, Dr. Scott Sperling discusses the article Joint Effects of Human Immunodeficiency Virus (HIV) and Cannabis on Neurocognition with first author Ashley Adams, MS and senior author Dr. Raul Gonzalez. This study explored the effects of cannabis use and HIV on neurocognition in a demographically diverse sample (N = 269). Results showed that participants who endorsed cannabis use (CB+) and had an HIV diagnosis (HIV+) were more likely to be labeled with a memory impairment compared to controls (CB-/HIV-). Addiitionally, the CB+/HIV- was twice as likely to be labeled with an executive functioning impairment compared to controls. Overall, results suggest that cannabis use confers risk for neurocognitive decline in HIV; however, risk must be weighted against potential effect on symptoms.

In this episode, Dr. Scott Sperling and student leader, Grace Goodwin, discuss the article The Association of Multilingualism with Diverse Language Families and Cognition Among Adults with and without Education in India with the senior author, Dr. Miguel Arce Rentería. This study leveraged the rich linguistic diversity across all socioeconomic gradients in India to understand how multilinguilism impacts cognition later in life in individuals with and without formal education. Participants were from The Longitudinal Aging Study in India-Diagnostic Assessment of Dementia which included 4,088 individuals, 54% of whom did not have formal education. Analyses employed education-stratified regression models. Results showed that for individuals with formal education, multilingualism was associated with better cognitive functioning. For individuals without formal education, results differed based on the similarity of languages known by the individual such that those who knew multiple languages that were more similar linguistically (over those who knew multiple dissimilar languages) had better executive functioning than monolinguals. This study adds to our understanding related to the impact of multilingualism (including language similarity) and education on cognition in an aging population.

In this episode, Dr. Scott Sperling and Dr. Elaine Schultz discuss the article p-Tau/Aβ42 ratio associates with cognitive decline in Alzheimer's disease, mild cognitive impairment, and cognitively unimpaired older adults with two the paper's authors, Dr. Ruchika Prakash and Michael McKenna. The goal of the study was to examine whether a CSF-based p-Tau/Aβ42 ratio predicted aspects of cognition (global cognitive functioning, episodic memory, and executive functioning) over a 2-year period (data collected at baseline, 6 months, 12 months, and 24 months). This study utilized data from 1,215 older adults through the Alzheimer's Disease Neuroimaging Initiative including those who were cognitive unimpaired, those with mild cognitive impairment, and those with Alzheimer's Disease. Results showed that the p-Tau/Aβ42 ratio predicted global cognitive decline and episodic memory decline in mild cognitive impairment and Alzheimer's disease and was able to predict decline in executive functioning across all group. This study highlights the potential impact of Alzheimer's-related pathology in the broader aging population on cognitive abilities, with particular impact on executive functioning.