『Mechanism of Action』のカバーアート

Mechanism of Action

Mechanism of Action

著者： Dr. Adam J. Brown
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 Discover how modern medicine was built. This podcast explores the careful, often overlooked history of how doctors and scientists identified diseases, uncovered their secrets in the lab, and developed treatments that transformed lives. Join us to appreciate the work behind the medicines we rely on today.© 2025 Good Prognosis Media & Publishing LLC 博物学 科学 自然・生態学 衛生・健康的な生活 身体的病い・疾患
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  • Blood, Salt and Sympathectomies: Early Interventions and Blood Pressure Management

    Blood, Salt and Sympathectomies: Early Interventions and Blood Pressure Management
    2025/12/01

    Before thiazides and ACE inhibitors, clinicians relied on bleeding, low-salt diets, metabolic experiments, and even nerve-cutting surgeries to manage dangerous blood pressure. This episode explains how these early interventions—and key discoveries about volume, salt, and baroreceptors—shaped our understanding of hypertension and paved the way for pharmacologic breakthroughs.

    Chapters
    • (00:00:00) - Introduction: Early Battles With Blood Pressure
    • (00:02:08) - Bloodletting: The First “Therapy”
    • (00:04:53) - Patient Story: “Mom, I Don’t Want to Die”
    • (00:06:59) - Sponsor Break: Dr. Clay’s Drainage Kit
    • (00:08:43) - Enter Salt: The Oldest Dietary Culprit
    • (00:14:05) - Diets & The Rise of the “Rice Houses”
    • (00:21:09) - Baroreceptors: The Nervous System’s Pressure Sensors
    • (00:25:11) - Sympathectomies: Cutting Nerves to Cut Pressure
    • (00:26:41) - Recap & What Comes Ne
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    28 分
  • Animal Cruelty, Obliterating Arteries, and Insurance Actuaries: How Medicine Recognized the Dangers of Hypertension

    Animal Cruelty, Obliterating Arteries, and Insurance Actuaries: How Medicine Recognized the Dangers of Hypertension
    2025/11/28

    We trace the origins of how medicine first understood and measured blood pressure. From early fluid-pressure experiments and invasive animal studies to the invention of the modern blood-pressure cuff, we follow the slow realization that chronically elevated blood pressure is dangerous. We also explore the long-standing debate surrounding "essential hypertension" and how research—from Janeway's observations to insurance-company data and the Framingham Study—ultimately shifted medical practice toward active treatment.

    Chapters
    • (00:00:00) - Intro: History of Blood Pressure
    • (00:01:35) - What is Blood Pressure
    • (00:03:53) - Normal vs High Blood Pressure
    • (00:04:48) - Histories View of Hypertension
    • (00:07:35) - The Origin of Blood Pressure Measurement
    • (00:09:12) - Stephen Hales & Animal Experiments
    • (00:12:44) - Measurement Devices
    • (00:15:55) - Early Clues of Danger: Kidneys, Hearts
    • (00:19:25) - What Famous Clinicians Believed
    • (00:24:31) - Hypertensions Dangers Emerge
    • (00:25:27) - Insurance Actuaries Enter the Scene
    • (00:27:20) - The Framingham Heart Study
    • (00:27:52) - Closing
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    29 分
  • Trailer: Introducing Mechanism of Action

    Trailer: Introducing Mechanism of Action
    2025/08/09
    Hosted by Dr. Adam Brown, a rheumatologist with a deep passion for medical history, Mechanism of Action invites you on a journey through the hidden chapters of modern medicine. From the first whispers of mysterious illnesses to the lab discoveries that revolutionized treatment, this show uncovers the fascinating stories behind the drugs we depend on.
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    1 分
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