“PRP contains everything the body needs to regenerate.” – Giuseppe Calloni

In this episode of Compound Wisdom, Steve Sood sits down with Giuseppe Calloni of RegenLab USA to break down what platelet-rich plasma (PRP) really is, how it’s made, and why Giuseppe believes the future of regenerative medicine is prevention—not just treatment.

Giuseppe shares a non-linear career path that starts in Milan, moves through a PhD in atomic physics in the UK, and spans oil & gas, chemical R&D, and biotech before he ultimately lands in regenerative medicine and becomes CEO. That “career without a plan” theme becomes a key thread: curiosity, learning, and global experience across France, Switzerland, China, and the U.S. shaped how he thinks about science, products, and patients.

From there, the conversation gets practical. Giuseppe explains RegenLab’s gel separation technology in simple terms: blood is drawn into a tube containing a specialized gel, spun in a centrifuge for about five minutes, and separated by density into layers—allowing clinicians to create platelet-rich plasma. He also highlights that PRP has existed for decades, expanding from early uses into sports medicine, injuries, hair restoration, aesthetics, gynecology, and orthopedics.

The episode then shifts into what makes RegenLab different in Giuseppe’s view: a data-first approach (patents, clinical data, publications) and a long-term strategy to navigate global regulation. Giuseppe describes the reality of waiting years for approvals—including a 10-year FDA timeline that eventually led to a PRP-based kit for diabetic chronic wounds being released with nationwide reimbursement. He argues the delays are frustrating but necessary if the goal is safety, efficacy, and real patient outcomes.

Finally, Steve and Giuseppe go wider: exosomes, stem cells, and the “hype cycle” in longevity. Giuseppe is candid about how exosomes became popular as a concept, but questions whether many products in the market are truly data-driven. He also explains why RegenLab stays focused on PRP and its next evolution—PRP plus tissue engineering approaches like hyaluronic acid scaffolds, and new minimally invasive implant ideas using electrospinning and 3D printing to help patients recover faster and avoid major surgeries. The throughline is clear: keep people moving, keep quality of life high, and prevent the decline before it becomes irreversible.

Takeaways

Giuseppe’s career path started in Milan and led to a PhD in atomic physics in the UK.

Curiosity drove him across oil & gas, chemical R&D, and then biotech.

He worked across Italy, France, Switzerland, China, and the U.S. before settling in America.

He became CEO at RegenLab after a collaboration that began when RegenLab was a client.

RegenLab is positioned as a science-based medical device company (patents, publications, clinical data).

PRP is created by separating blood components by density using a specialized gel + centrifuge process.

The gel transitions state under spinning, allowing clean layer separation in about five minutes.

After separation, the platelet concentration can be increased by inverting the tube multiple times.

PRP has been used in the market since the 1970s and expanded into many clinical applications.

Use cases discussed include sports injuries, pain relief, hair loss, aesthetics, gynecology, and knee osteoarthritis.

Giuseppe claims PRP can regenerate at the cellular level via growth factors in platelets.

He says PRP is the only truly effective hair regeneration treatment currently.

RegenLab’s PRP platform includes “PRP plus” approaches and tissue engineering directions.

Combining PRP with hyaluronic acid can act as a scaffold and prolong time between treatments.

Giuseppe emphasizes prevention as the core direction of regenerative medicine.

RegenLab expanded...