『Keratoconus, An Inflammatory Disease in Disguise』のカバーアート

Keratoconus, An Inflammatory Disease in Disguise

Keratoconus, An Inflammatory Disease in Disguise

著者： Saikumar Gandapodi
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For decades, textbooks defined keratoconus as a 'non-inflammatory' degenerative thinning of the cornea. But a growing body of peer-reviewed research is challenging that assumption, revealing elevated inflammatory cytokines, oxidative stress, mitochondrial dysfunction, and altered protease activity in the tears and corneal tissue of affected patients. In this episode, host Maya Iyer sits down with Dr. Saikumar Gandapodi, Board-Certified Doctor of Oriental Medicine, Ayurvedic practitioner, and Founder and Director of Netra Eye Institute, to explore why keratoconus may be far more of an inflammatory and systemic disease than its classic definition suggests. Together they trace the mechanistic story — from matrix metalloproteinases and IL-6 and TNF-alpha in tear film, to reactive oxygen species, glutathione depletion, and the biomechanical collapse of collagen crosslinks. Dr. Gandapodi explains where conventional pillars like corneal crosslinking, rigid contact lenses, and transplantation excel, and where adjunct opportunities may exist to address the underlying biological terrain, including the gut-eye axis, eye rubbing, atopy, and oxidative burden. The conversation introduces Netra Restoration Therapy (NRT) as an integrative, complementary framework — never a replacement for standard care — and interprets traditional herbal medicine through the modern lenses of network pharmacology and systems biology. Balanced, evidence-aware, and intellectually honest, this episode is for clinicians, patients, and curious minds who want to understand keratoconus not as an isolated corneal shape problem, but as a whole-person biological process.Copyright 2026 - Netra Eye Institute 代替医療・補完医療 衛生・健康的な生活 身体的病い・疾患
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  • Keratoconus - An Inflammatory Disease in Disguise

    Keratoconus - An Inflammatory Disease in Disguise
    2026/07/02

    For decades, textbooks defined keratoconus as a 'non-inflammatory' degenerative thinning of the cornea. But a growing body of peer-reviewed research is challenging that assumption, revealing elevated inflammatory cytokines, oxidative stress, mitochondrial dysfunction, and altered protease activity in the tears and corneal tissue of affected patients. In this episode, host Maya Iyer sits down with Dr. Saikumar Gandapodi, Board-Certified Doctor of Oriental Medicine, Ayurvedic practitioner, and Founder and Director of Netra Eye Institute, to explore why keratoconus may be far more of an inflammatory and systemic disease than its classic definition suggests.
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