Joseph Takahashi: Circadian Clock Proteins, Metabolism, Neuroplasticity, and Aging
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Joseph Takahashi: Circadian Clock Proteins, Metabolism, Neuroplasticity, and Aging
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Optimal health depends critically on maintenance of an evolutionarily ancient circadian clock that ticks within all cells of the body and brain. Discovery of the genes that encode the core proteins of the molecular clock have revealed how the clock works and, importantly, how the clock influences health and resilience. Joseph Takahashi discovered the gene for CLOCK which is one of four proteins that control circadian rhythms. In this episode I talk with Joe about his discoveries concerning how the molecular clock functions, how the clock influences energy metabolism, the consequences of disruption of the clock for health, and how we can improve our circadian rhythms by, for example, daily time-restricted eating.
LINKS
Takahashi laboratory
https://labs.utsouthwestern.edu/takahashi-lab
How the cellular circadian clock works
https://pmc.ncbi.nlm.nih.gov/articles/PMC10631358/pdf/nihms-1930368.pdf
Daily time-restricted eating and circadian rhythms
https://www-annualreviews-org.proxy1.library.jhu.edu/docserver/fulltext/10.1146/annurev-nutr-112525-011241/annurev-nutr-112525-011241.pdf?expires=1779798437&id=id&accname=ar-223467&checksum=908E9889190B85725CE892E63BB5413C