Title: Inside Clinical Trials – What Happens After the Lab?

Episode Summary: Clinical trials are the bridge between discovery and real-world treatments—but what really happens during these studies? In this episode of Talking in the Woods, host Christopher Wood breaks down the phases of clinical trials and why they matter for drug development.

What You’ll Learn in This Episode:

• Phase I: Safety and tolerability in healthy volunteers
• Phase II: Finding the right dose and measuring early effectiveness
• Phase III: Large-scale confirmation and global studies
• Why trials fail and what biomarkers reveal about disease activity
• The importance of patient participation and diversity in research

Resources Mentioned

• FDA Clinical Research Overview: https://www.fda.gov/patients/drug-development-process/step-3-clinical-research
• NIH Inclusion Policy: https://grants.nih.gov/policy/inclusion
• Clinical Trials Database: https://clinicaltrials.gov

References

1. Clinical Trial Phases Explained FDA: “Step 3: Clinical Research.” Available at: https://www.fda.gov/patients/drug-development-process/step-3-clinical-research
2. Why Trials Fail & Biomarkers Matter Ioannidis JPA. “Why Most Clinical Research Is Not Useful.” Published in PLoS Medicine, 2016. Read the full article: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002049
3. Patient Participation & Diversity in Research NIH: “Inclusion of Women and Minorities in Clinical Research.” Available at: https://grants.nih.gov/policy/inclusion

🎧Subscribe on Apple Podcasts, Spotify, or your favorite platform.

🎧 Tune in to discover how clinical trials shape the future of medicine.