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In Episode 2 of Inpatient Update, your host, Dr. Mason Turner, breaks down three studies that could change what you do on rounds tomorrow:

• Phenobarbital for alcohol withdrawal — fewer admissions and shorter ED stays during the IV lorazepam shortage natural experiment.
• Conservative dialysis in AKI requiring RRT (LIBERATE-D) — less routine dialysis, more kidney recovery?
• Postoperative transfusion thresholds in high–cardiac-risk patients (TOP Trial) — is 7 still enough?

Articles & PubMed Links

1. Fewer Admissions, Shorter Stays: Phenobarbital Use for Alcohol Withdrawal in the Emergency Department
   Academic Emergency Medicine (2025)
   PubMed: https://pubmed.ncbi.nlm.nih.gov/41147831/
2. A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury (LIBERATE-D Trial)
   JAMA ( 2026)
   PubMed: https://pubmed.ncbi.nlm.nih.gov/41201895/
3. Liberal or Restrictive Postoperative Transfusion in Patients at High Cardiac Risk: The TOP Randomized Clinical Trial
   JAMA (2025)
   PubMed: https://pubmed.ncbi.nlm.nih.gov/41205227/

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In this pilot episode of Inpatient Update, your host, Dr. Mason Turner, breaks down three clinically relevant studies that could change how you practice tomorrow on the wards:

1. Pre-ERCP antibiotic prophylaxis — does it reduce post-procedure infections in biliary obstruction?
2. Reduced-dose apixaban after 6 months in cancer-associated VTE — noninferior and potentially safer?
3. Early initiation of beta-blockers in cirrhosis with uncomplicated ascites — early signals of benefit.

Practical take-homes, clear links to evidence, and what to tell your team on rounds.

Articles & PubMed Links

1. Is Antibiotic Prophylaxis Warranted in All Patients With Biliary Obstruction Undergoing Endoscopic Retrograde Cholangiopancreatography?: A Systematic Review and Meta-Analysis
   PubMed: https://pubmed.ncbi.nlm.nih.gov/40961256/
2. Extended Reduced-Dose Apixaban for Cancer-Associated VTE (API-CAT)
   PubMed: https://pubmed.ncbi.nlm.nih.gov/40162636/
3. Efficacy and Safety of Carvedilol in Cirrhosis Patients With New-Onset Uncomplicated Ascites Without High-Risk Esophageal Varices (CARVE-AS Trial)
   PubMed: https://pubmed.ncbi.nlm.nih.gov/40689908/