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Keywords

Lung research, Respiratory tract, Human lung explants, Organoids, Air-liquid interface cultures, Infections, Drug testing, Disease mechanisms, Virology

Summary

In this episode of the Young Immunologist Podcast ImmunoChat, host Pia Leipe interviews Dr. Saskia Hinse, a postdoc at the University clinic Münster at the Institute of molecular Virology, to discuss models of the respiratory tract. They explore the use of human lung explants, organoids, and air-liquid interface cultures in lung research, focusing on their applications in studying infections, drug testing, and understanding disease mechanisms. The conversation highlights the advantages and challenges of these models, emphasizing their role in complementing traditional in vitro and in vivo experiments.

Takeaways

• Lung explants are small pieces of human lung tissue used for research.
• Organoids are grown from type II pneumocytes and can be maintained for months.
• Air-liquid interface cultures mimic the upper respiratory tract.
• These models help study infections and drug testing.
• Lung explants and organoids complement in vitro and in vivo experiments.
• Challenges include tissue availability and heterogeneity.
• Human tissue models are key for understanding disease mechanisms.

Please find here links to publications using the models discussed today - Lung explants, Organoids and ALIs:

https://pubmed.ncbi.nlm.nih.gov/39248230/

https://pubmed.ncbi.nlm.nih.gov/36423831/

Contact details

• Dr. Saskia Sophie Hinse
• LinkedIn: https://www.linkedin.com/in/saskia-sophie-hinse-0a273a398/

Support the show

The Podcast is hosted by Pia Madeleine Leipe -
www.linkedin.com/in/pia-madeleine-l-75b749207

The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US
https://www.yefis.org/

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Keywords

Multiple Sclerosis, Pregnancy, Autoimmune Diseases, Immune Tolerance, GDF15, Neuroimmune Crosstalk, Reproductive Immunology, Maternal Health, Research Challenges, MS Treatment

Summary

In this episode of the Young Immunologist podcast, Nóra Balzer interviews Jana Sonner, a postdoc at the University Medical Center in Hamburg, discussing the intersection of multiple sclerosis (MS) and pregnancy. They explore how autoimmune diseases typically affect women during their reproductive years, the unique immunological changes that occur during pregnancy, and the implications for maternal and fetal health. The conversation delves into the mechanisms of maternal immune tolerance, the role of GDF15, and the latest research findings on MS and pregnancy. Jana emphasizes the need for more research in reproductive immunology and the importance of including pregnant women in clinical trials to improve treatment outcomes.

Takeaways

• Pregnancy can suppress disease activity in autoimmune diseases.
• Autoimmune diseases often onset during women's reproductive years.
• MS does not typically affect fertility or pregnancy outcomes.
• Disease-modifying therapies may pose risks during pregnancy.
• Maternal immune tolerance is crucial for pregnancy success.
• GDF15 plays a role in immune regulation during pregnancy.
• Peripheral immune system adapts significantly during pregnancy.
• Exclusive breastfeeding may lower postpartum relapse risk in MS.
• Research in reproductive immunology is still underfunded and underexplored.
• Inclusion of pregnant women in clinical trials is essential for better treatment.

Please find some links to work both on MS in general and pregnancy and MS

• https://www.nejm.org/doi/10.1056/NEJM199807303390501?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.gov
• https://link.springer.com/article/10.1007/s00281-016-0584-y
• https://www.nature.com/articles/s41583-024-00823-z
• https://www.nature.com/articles/s41577-022-00718-z

Contact details

• Contact: Dr. Jana Sonner, jana.sonner@zmnh.uni-hamburg.de
• Webpage Institute of Neuroimmunology and Multiple Sclerosis (INIMS): https://www.inims.de

Support the show

The Podcast is hosted by Nóra Balzer -
https://www.instagram.com/balzernora/
https://www.linkedin.com/in/n%C3%B3ra-balzer-253a767b/?originalSubdomain=de


The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US
https://www.yefis.org/

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keywords

academic integrity, plagiarism, intellectual property, research ethics, PhD students, collaborations, scientific publications, open access, patents, copyrights

summary

In this podcast episode, Nora Balzer (Dr rer Nat) discusses the complexities of intellectual property in academia, particularly in the context of a case involving a PhD student accused of plagiarism. The conversation explores the balance between sharing research for public good and protecting intellectual achievements, the challenges of collaborations, and practical advice for PhD students navigating these issues.

takeaways

• Sophie’s case highlights the complexities of academic integrity - reference: https://www.spiegel.de/lebenundlernen/uni/professor-contra-doktorandin-wer-klaut-hier-bei-wem-a-776909.html - accessed on 27-02-2025.
• Intellectual property in academia is often misunderstood.
• The need to protect research can conflict with sharing knowledge.
• Patents and copyrights are crucial but challenging to navigate.
• Open access aims to make research freely available but has costs.
• Collaborations can complicate ownership of research outcomes.
• PhD students should choose their supervisors wisely.
• Reading contracts is essential for understanding rights.
• Building a support network is vital for early career scientists.
• Emotional responses to credit disputes should be managed rationally.

Support the show

The Podcast is hosted by Nóra Balzer -
https://www.instagram.com/balzernora/
https://www.linkedin.com/in/n%C3%B3ra-balzer-253a767b/?originalSubdomain=de


The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi

Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US
https://www.yefis.org/