Immune reviews new research that shows a boost in T cell function after eating and the potential for the cGAS-STING pathway to be a new lupus therapeutic target.

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• T cell immunity boosted after eating (Nature, 2026)
• Inhibiting autoimmunity through TLR7-cGAS (Nat Comm, 2026)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
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Stacy Horner discusses her work on innate detection of viruses, viral countermeasures, and the role of m(6)A RNA modifications in regulating antiviral immunity.

Host: Cindy Leifer

Guest: Stacy Horner

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• Hepatitis virus proteases block host response (J Virol, 2012)
• Host RNA binds to MAVS (Science, 2024)
• m6A modifications modify innate response to viruses (Cell Chem Biol, 2024)
• UFMylation coordinates MAVS assembly for antiviral responses (bioRxiv, 2025)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
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Scott Smith talks about his research on cloned individual antibodies and how those studies have shifted his thoughts on the role of IgE in parasite defense and food allergy.

Host: Cindy Leifer

Guest: Scott Smith

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• Complement control proteins in poxvirus evasion (J Virol, 2000)
• Complement control protein reduces xenotransplant rejection (Transpl Proc, 2002)
• Engineering therapeutic antibodies (J Allergy Clin Immunol, 2023)
• Antigens in peanut allergy anaphylaxis (J Allergy Clin Immunol, 2025)
• Using human antibodies to identify parasite antigens (J Allergy Clin Immunol, 2022)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
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Information on this podcast should not be construed as medical advice.

Kathryn Knoop and Marion Brunck join the Immune team to talk about their research and their podcast "Mucosal Immunology".

Guests: Kathryn Knoop and Marion Brunck

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• Knoop: Oral tolerance in early life review
• Knoop: Gamma delta T cells in neonatal sepsis
• Knoop: EGF and IgA in breastmilk
• Brunck: FcGR's in PMNS
• Brunck: CRISPR KO to study FcGR's in human PMN
• Brunck: Leukocytes in breastmilk review
• Mucosal Immunology podcast
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
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Information on this podcast should not be construed as medical advice.

Jenna Guthmiller talks about how she became interested in immunology and her exciting research on how different responses to vaccines and infection shape future responses to infection.

Host: Cindy Leifer

Guest: Jenna Guthmiller

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• Broadly neutralizing flu antibodies (Nature, 2022)
• First exposure antibodies to H1N1 flu (Sci Transl Med, 2021)
• Long lasting B cells to chimeric flu vaccine (Immunity, 2025)
• Vaccine strategies to target HA anchor epitope (Nat Comm, 2025)
• Pre-existing immunity shapes flu response (Sci Trans Med, 2020)
• From Immune 35: SARS-CoV-2 infection severity linked to anti-spike (mBio, 2021)
• Guthmiller lab
• Time stamps by Jolene Ramsey. Thanks!

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Information on this podcast should not be construed as medical advice.

Immune discusses a snippet on how EBV infection alters the immunopeptidome and promotes multiple sclerosis, and a paper on head and neck cancers harboring bacteria that create an immunosuppressive environment and promote immunotherapy resistance.

Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker

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• EBV, Golli-MBP presentation and multiple sclerosis (Cell, 2026)
• Intratumoral bacteria promote resistance to cancer immunotherapy (Nat Cancer, 2026)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
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Gabriel Nunez discusses the discovery of NOD-like receptors, NOD1 and NOD2, in inflammatory bowel disease and how travel and taking a moment to enjoy local culture and art influences his creativity.

Host: Cindy Leifer

Guest: Gabriel Nuñez

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• HLA and antigen presentation (Hum Immunol, 1987)
• Bcl2, cell death, and B cells (Nature, 1991)
• Discovery of NOD1 (J Biol Chem, 1999)
• Discovery of NOD2 (J Biol Chem, 2001)
• Mutation in NOD2 and connection to Crohn's disease (Nature, 2001)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
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Martha Alexander-Miller discusses why newborn and infant immune responses to vaccines are generally less effective and how we can make vaccines safer and more effective.

Guest: Martha Alexander-Miller

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• MicrobeTV Discord Server
• Flu HA nanoparticle vaccine (Nat Comm, 2025)
• Sex-dependent adjuvant activity in newborns (Vaccines, 2024)
• Flu vaccine with R848 adjuvant (Vaccines, 2023)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
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Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.