Episode Summary:

In this episode of Healthcare Algorhythm, Dr. William Strimel is joined by Paulo J. Machado, fractional co-founder and healthcare entrepreneur, to explore how startups can build healthcare that truly matters. The conversation centers on moving beyond flashy technology to create solutions that improve patient outcomes, support providers, and scale compassionate care.

Paulo shares how his background in data science, life sciences strategy, and healthcare innovation shaped his values-driven approach to entrepreneurship. He explains the role of fractional co-founders in helping early-stage companies bridge operational and commercialization gaps while staying focused on mission and impact. The episode also examines what makes healthcare startups investable, from aligned teams and clear purpose to technology that serves real-world needs, and offers a grounded perspective on building sustainable, meaningful healthcare businesses.

Key Takeaways:

1. Why fractional co-founders can accelerate early-stage healthcare startups
2. How mission, values, and purpose drive long-term startup success
3. The importance of human-centered solutions alongside technology
4. Innovations in mental health, cardiovascular care, and cancer treatments
5. Systemic challenges in healthcare and strategies to overcome them
6. How clinician-entrepreneurs are shaping the future of healthcare startups
7. What investors look for in impactful, scalable healthcare solutions

Golden Nugget:

“Technology alone won’t solve healthcare impact comes from aligning purpose, execution, and compassion for patients and providers alike.”

Connect with Paulo J. Machado:

1. LinkedIn: linkedin.com/in/paulojmachado

Listen Now & Subscribe:

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Healthcare Algorhythm breaks down the systems, strategies, and technologies shaping modern medicine, turning complexity into clarity, one conversation at a time.