The French Bulldog exhibits exceptional dermatological vulnerability, resulting from the complex interaction between its anatomical conformation and specific genetic factors1. Its brachycephalic morphology leads to the formation of deep skin folds, creating a warm, humid microclimate favorable to maceration and intertrigo.... Concurrently, a defective skin barrier, marked by a deficiency in filaggrin and ceramides as well as mutations in the PROM1 and SLAMF1 genes, weakens the epidermis against allergens....

This vulnerability allows for the frequent expression of atopic dermatitis, affecting up to 20% of the breed, often from a young age10.... The disease is characterized by intense inflammation mediated by interleukin-31 and chronic cutaneous dysbiosis. Bacterial superinfections (notably with Staphylococcus pseudintermedius organized in biofilms) and fungal infections (Malassezia) are almost systematic, as is the predisposition to juvenile demodicosis linked to an immune defect....

Therapeutic management requires a strict multimodal strategy. It prioritizes the cytological diagnosis of infectious complications, the restoration of the skin barrier, and the control of pruritus through advanced therapies, such as JAK inhibitors or monoclonal antibodies, aiming to sustainably stabilize this precarious cutaneous balance