Weight loss plateaus on GLP-1 therapies such as Wegovy and Zepbound are increasingly understood as a function of biological adaptation rather than patient noncompliance.

In this episode I will be discussing CagriSema, an investigational combination therapy expected to launch between late 2026 and early 2027. The treatment combines semaglutide and cagrilintide, targeting complementary mechanisms that regulate appetite and satiety.

Clinical trial data indicate weight reduction of up to 22.7%, suggesting improved efficacy relative to existing monotherapies.

The development reflects a broader shift toward combination-based treatment models, consistent with approaches used in managing chronic conditions such as diabetes and hypertension.

Listen to the episode for a closer look at what this could mean for treatment pathways and patient outcomes.

Episode Highlights:

• Why plateaus happen and what your body is actually doing

• What CagriSema is and how its two-ingredient formula works

• What the REDEFINE trials show including how it stacks up against Tirzepatide

• Who this medication is most likely to help

• Why the best plan is still the one that's working for you right now

Connect with Dr. Alicia Shelly:

• Website | drshellymd.com

• Facebook | www.facebook.com/drshellymd

• Instagram | @drshellymd

• Linked In | www.linkedin.com/in/drshellymd

• Twitter | @drshellymd
  

About Dr. Alicia Shelly

Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH. Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014. In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss, where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, "Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''.

Resources:

FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!) 👉 Click