During this podcast episode, Mandy and Corey continue their conversation about how to read a scientific paper, so their girlfriends can make important evidenced-based health decisions.

We discuss two contrasting papers on Menopausal Hormone Therapy (MHT) and its implications for neurodegenerative diseases like dementia, Alzheimer's, and Parkinson's.

First, we dissect a study from the University of Arizona, which analyzes insurance data spanning a decade, and concludes that regular use of hormone therapy was protective against Alzheimer's disease and all forms of dementia.

https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12174

The figure showing how age functioned as a modifier in the above study:

https://alz-journals.onlinelibrary.wiley.com/cms/asset/fe139a22-4d3d-4c52-85e3-3fa75aaae6dc/trc212174-fig-0003a-m.jpg

Next, we assess a study from Denmark with conflicting results and various inconsistencies.

https://www.bmj.com/content/381/bmj-2022-072770

An editorial on the above, that Corey mentions:

https://www.bmj.com/content/381/bmj.p1404

We then talk about interpreting scientific research, critical thinking, and potential biases, reinforcing the idea that scientific understanding evolves over time.

Mandy recommends two reliable resources for further research around nutrition and exercise science:

Dr. Bill Campbell:

https://www.billcampbellphd.com/

https://www.instagram.com/billcampbellphd/?hl=en

Dr. Layne Norton:

https://biolayne.com/reps/

https://www.instagram.com/biolayne/?hl=en

https://twitter.com/BioLayne?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor

https://www.youtube.com/channel/UCqMBA83S0TnfTlTeE5j1mgQ

(And a special treat… both in one clip!)