What happens when an established treatment regains its effectiveness against resistant disease?

In this episode of the Syneos Health Podcast: Early Signals, Wael Harb, MD, Head of R&D and Scientific Strategy in Oncology at Syneos Health, sits down with Jason Litten, MD, Chief Medical Officer of Genelux, to discuss the evolving role of oncolytic virus therapy in oncology and its potential to reshape treatment strategies for patients with difficult-to-treat cancers.

Together, they explore the science behind Olvi-Vec, a modified vaccinia oncolytic virus designed to directly attack tumors, remodel the tumor microenvironment and potentially restore sensitivity to platinum-based chemotherapy. The conversation examines emerging approaches to immuno-oncology, the future of combination therapies and the opportunities and challenges of advancing innovative oncology programs from early development through pivotal clinical trials.

Topics include:

• Why oncolytic viruses are gaining renewed attention in oncology drug development
• The science behind Olvi-Vec and its potential role in platinum-resistant ovarian cancer
• How tumor microenvironment remodeling may help restore sensitivity to platinum-based chemotherapy
• Combining oncolytic virus therapy with chemotherapy, immunotherapy and future treatment modalities
• Opportunities and challenges in developing novel oncology therapies for solid tumors
• Expanding oncolytic virus approaches beyond ovarian cancer into additional tumor types
• Emerging trends shaping the future of immuno-oncology and precision medicine
• Lessons from clinical development across targeted therapies, cell therapies and oncolytic viruses

The views expressed in this podcast belong solely to the speakers and do not represent those of their organization.

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