『[EP.11]The Shocking Truth Why Cortisol Is The Rapid Aging Hormone』のカバーアート

[EP.11]The Shocking Truth Why Cortisol Is The Rapid Aging Hormone

[EP.11]The Shocking Truth Why Cortisol Is The Rapid Aging Hormone

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 Dr. Joel Rosen:All right, I am super excited to be interviewing Georgi Dinkov a second time. For those of you who know who he is, he doesn’t need a bio. But for those that may not know who Georgie didn’t cough, is, there’s so much to say and so much to get to today. I’m going to abbreviate his bio, but basically, he is a self-taught guy. His interest in health topics continued after he left his job. While researching aspirin and its effects on the brain circa 2011 11, he stumbled on Ray Pete’s website, and I think that’s what dug down into the bioenergetics field. His ideas on Bennett bioenergetics which is controlled by dietary and environmental factors as the ultimate causal factor in health disease and even aging immediately appealed to Georgia. And since then, he’s been doing research in that field. So Georgia, I’m super excited to get started. Thank you so much for joining us. Georgi Dinkov:Thanks for inviting me again. Hopefully, it will be I’ll be useful to your listeners. Oh, yes. Dr. Joel Rosen:Listen, I went through that interview several times. And I came up with some great questions for you today. So for those who want to hear the past interview, we got into metabolic flexibility. We’ll leave links there. And Georgie, as I was telling you, before we got started, I walked away with a lot of aha cars that were contrary to what’s being taught. And I’ve gone down the cortisol rabbit hole, if you will. And even just our conversation when we just had that amazing insight has shifted my perspective. And I wanted to share that. So cortisol is not what we thought it was the truth behind it is it’s a rapidly aging stress hormone. One of the sacred cows or the contrarian thinking is that cortisol is anti-inflammatory when in fact, it’s pro-inflammatory. So maybe in your in your amazing way of bringing difficult concepts into an easy, understandable way. Explain that to the person who thought, well, cortisol is anti-inflammatory, and I take prednisone hydrocortisone, for an anti-inflammatory immune response or suppression, but ultimately, it’s putting more oil on the fire perhaps. So maybe let’s go into that. Georgi Dinkov:I think probably the best comparison that I can give you is with opioids, which are widely used for pain management in the medical field, and a lot of people are abusing them for these pain-relieving properties. It’s very well known that basically, if you continue using opioids, you develop tolerance to them, and then it and not only that, you’re going to start needing higher and higher doses to be able to tamp down the same level of pain. But eventually, if you try to wean off or you stop the opioids, there will be a baseline of pain, that’s going to shoot up tremendously. In other words, you’re going to be in a worse position than you started. And the pathways for the opioids are fairly well known. They increase reluctant histamine and serotonin, and they also increase the expression of an endotoxin receptor known as TLR four. All of these are known to be involved in chronic pain. So while you’re taking opioids back activation of the opioid receptor, which is a receptor that our endogenous opioids known as the better endorphins also activate, yes, you are kind of inhibiting the signals, at least the peripheral signals from for pain to reach the brain and that are kind of registered as a pain signal. But it’s while you’re doing that you’re up-regulating the machinery that causes these pain signals to travel much more rapidly. So as soon as you stop the opioid, you’re in a worse position than where you started. So you kind of like, you know, in a catch-22 or, or actually, once you, once you start, you can stop unless you’re taking care of, you know, kind of like, unless you also take care of reducing these inflammatory mediators that were upregulated while using the opioids. And most people are not doing that simply because for a lot of, you know, whenever you prescribe opioids for pain, there’s there’s little concern, and now it’s starting to become a concern. However there was little concern about the long-term effects on pain. Now, doctors are starting to find out through various long-term studies that people who are using opioids long-term, end up being worse, right? Their pain starts to become unmanageable. And once they become resistant to the opioids, there’s very little you can do for them. And maybe the opioids aren’t the kind of like the end stage of pain treatment. In the hospital, they’re usually given to terminal cancer patients, or just in general terminal people just to kind of like ease the transition to them dying. But it’s really like a last resort step. So if patients stop responding to opioids, then there’s very little that the doctor can do for them, or at least that’s that’s what they think. So there wasn’t much of a thought to this process. But now they’re starting to find out that...
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