『Dr. Ursa Brown Glaberman & Dr. Karthik Giridhar- Managing Capiva-sertib & the AKT Path-way in 2L mBC』のカバーアート

Dr. Ursa Brown Glaberman & Dr. Karthik Giridhar- Managing Capiva-sertib & the AKT Path-way in 2L mBC

Dr. Ursa Brown Glaberman & Dr. Karthik Giridhar- Managing Capiva-sertib & the AKT Path-way in 2L mBC

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How are we navigating the evolving landscape of second-line treatment for metastatic HR-positive, HER2-negative breast cancer?In this full-length discussion, Dr. Ursa Brown-Glaberman and Dr. Karthik Giridhar explore one of the most rapidly evolving areas in breast oncology: treatment selection after progression on first-line endocrine therapy and CDK4/6 inhibitors.The conversation examines how molecular profiling, ctDNA testing, AKT pathway targeting,PIK3CA alterations, ESR1 mutations, and emerging biomarkers are reshaping decision-making in the second-line setting. The experts also discuss how they approach endocrine therapy sequencing, when to transition to ADCs, and how toxicity, quality of life, and patient preferences influence treatment selection.Topics discussed include:Second-line treatment strategies in HR-positive metastatic breast cancerEndocrine therapy sequencing after CDK4/6 inhibitorsESR1 mutation testing and ctDNA monitoringTissue biopsy versus liquid biopsyPIK3CA mutations and targeted therapiesCapivasertib versus alpelisib decision-makingAKT pathway inhibition in metastatic diseaseGermline BRCA and PALB2 testingBiomarker-driven treatment selectionWhen to transition from endocrine therapy to ADCsQuality of life considerations in metastatic breast cancerThe future of personalized treatment sequencingAs the treatment landscape continues to expand, understanding how to personalize second-line therapy has become one of the most important challenges in modern breast cancer care.Subscribe for more expert oncology discussions, breast cancer treatment updates, and clinical insights from leading specialists.–Thanks for watching!Our podcasts are also available on:Spotify - ⁠https://spotf.fi/chm-podcast⁠Amazon Music - ⁠https://amazn.so/chm-podcast⁠Apple Podcast - ⁠https://podcasts.apple.com/us/podcast...⁠Castbox - ⁠https://castbox.fm/vh/6735434⁠Goodpods - ⁠https://goodpods.com/profile/chm-111066⁠iHeartRadio - ⁠https://iheart.com/podcast/291542082⁠Pocket Casts - ⁠https://pca.st/3ncdh11o⁠–Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences.We’re an integrated marketing company that produces world-class content and curated peer to peer live experiences.We specialize in:Peer to peer interviews, panels & round-tablesCurated live events & conferencesProfessional in-depth content & research updatesInteractive learning modules & webinarsLive & on-demand webcasts & podcastsLearn more about us here - ⁠https://communityhealth.media⁠
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