What if ALS-one of the most devastating neurological diseases-is closer to being treatable than ever before? What if the cure is not decades away, but within reach in our lifetime?

In this powerful episode of Impossible Dreams, host Aaron Lazar sits down with Dr. Merit Cudkowicz-one of the world's leading ALS researchers and clinicians, the Julieanne Dorn Professor of Neurology at Harvard Medical School, and Chief of Neurology at Massachusetts General Hospital. Dr. Cudkowicz, affectionately known as the "greatest ALS doctor in the world" by countless patients, has dedicated her career to finding better treatments and ultimately a cure for ALS since witnessing the discovery of the first ALS gene in 1993.

This conversation is both deeply scientific and profoundly human. Dr. Cudkowicz walks through the challenging journey of ALS diagnosis-why it typically takes a year and 3-4 doctors before patients get answers-and explains the complexity of a disease that mimics many other conditions. She shares the groundbreaking advances happening right now, from the remarkable success of SOD1 gene therapy (which can halt or even reverse progression in certain patients) to the new wave of therapies targeting TDP-43 protein, the underlying biology present in nearly all ALS cases.

Throughout this episode, Dr. Cudkowicz's message is clear and urgent: "I don't think curing ALS is impossible. I absolutely think it's possible." She explains why staying connected to research centers, being part of the ALS community, maintaining physical and mental well-being, and never giving up hope are essential for patients navigating this disease. This episode is not just for those living with ALS, it’s for anyone who is living through the unknown of a life-changing diagnosis or has ever cared for someone who has. It's about spreading hope and community in the face of what feels impossible

Guest Bio:

Dr. Merit Cudkowicz is the Julieanne Dorn Professor of Neurology at Harvard Medical School and Chief of the Department of Neurology at Massachusetts General Hospital. A chemical engineer from MIT who went on to complete her medical training at Harvard, Dr. Cudkowicz has been at the forefront of ALS research since 1993, when her mentor Dr. Robert Brown discovered the first ALS gene (SOD1). She is the founder and director of the Healey ALS Platform Trial, a revolutionary multi-drug testing system that is dramatically accelerating the pace of ALS drug development. Dr. Cudkowicz has dedicated her career to clinical trials, patient care, and translating laboratory discoveries into treatments that can help people living with ALS.

Learn more about Dr. Merit Cudkowicz:

Mass General Neurology

Healey ALS Platform Trial

Harvard Medical School Faculty Profile

LIVE YOUR IMPOSSIBLE DREAMS

✨ Subscribe, listen, and believe.

Presented by the ALS Network

Produced by EVRYBDY Studios

Learn more at Aaron Lazar

Instagram: @impossibledreamspodcast

YouTube: @ALImpossibleDreams

Apple: