Creatine Monohydrate: The Gold Standard Comparing Solubility and Bioavailability

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Many creatine supplement manufacturers claim their product is superior to creatine monohydrate (CrM) because it is more soluble.
The sources state that solubility and bioavailability are not the same thing.
Creatine monohydrate is nearly 100% bioavailable, meaning almost all of the CrM consumed is absorbed and used by the body.
This high bioavailability is not affected by its solubility. Even if some CrM is undissolved in a glass of water, it will be absorbed by the body.
Manufacturers often make misleading comparisons when discussing solubility. For example, one study compared the solubility of creatine hydrochloride (Cr-HCl) to CrM at very different pH levels, misrepresenting real-world solubility.
The main benefit of increased solubility in alternative creatine forms is improved mixability; they dissolve more readily in water.
This does not translate to increased absorption or effectiveness.
No alternative form of creatine has been scientifically proven to be more bioavailable or effective than CrM.
The sources recommend CrM because it is:
- The most studied form of creatine and has a well-established safety and efficacy profile.
- The most affordable form of creatine.
The ability of a product to dissolve easily does not mean it is better absorbed and utilized by the body. When choosing a creatine supplement, scientific evidence should be prioritized over marketing claims.

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