The article explores the potential of curcumin, a natural polyphenolic substance extracted from turmeric, to reduce Delayed-Onset Muscle Soreness (DOMS) and support athletic recovery. DOMS is caused by microscopic muscle fiber tears and subsequent inflammation, involving the release of reactive oxygen species and inflammatory markers like COX-1 and COX-2. Curcumin demonstrates promising anti-inflammatory and antioxidant effects by suppressing inflammatory markers, including NF-B, IL-6, TNF-ɑ, and specifically COX-2, thereby reducing muscle damage. Studies detailing optimal timing and dosage have varied, showing significant DOMS reduction when curcumin was ingested before and after exercise, with recommended dosages ranging from 150 mg to 1,500 mg daily, often broken into multiple doses. However, practitioners must acknowledge that curcumin is not risk-free. Individual variability in tolerance, absorption, and metabolism is significant, and side effects like gastrointestinal issues are common. Furthermore, curcumin acts as an iron chelator and can reduce the effectiveness of certain drugs, such as tamoxifen. To enhance effectiveness, curcumin is often combined with piperine (from black pepper), which can increase its bioavailability by 20-fold. The goal remains achieving the maximum therapeutic benefit with the fewest side effects, requiring practitioners to start with low doses and carefully monitor patient response.