In this episode of Around the Rheum, hosts Dr. Daniel Ennis and Dr. Janet Pope sit down with Dr. Luke Chen for a deep dive into an approach to patients presenting with hypereosinophilia. Recorded at the Canadian Rheumatology Association (CRA)’s 2026 Annual Scientific Meeting in Halifax, the conversation explores how hematologists, rheumatologists, allergists, infectious disease specialists, and others work together to diagnose and manage these complex disorders.

Dr. Chen discusses the broad differential diagnosis behind eosinophilia — from Eosinophilic Granulomatosus with Polyangiitis (EGPA) and IgG4-related disease to parasitic infections to rare hematologic disorders to 'Idiopathic' Hypereosinophilic Syndrome (I-HES) — and the uncertainty clinicians often face when distinguishing overlapping eosinophilic diseases. The discussion also highlights emerging therapies including IL-5 inhibitors, JAK inhibitors, interferon, and biologics, alongside the practical realities of access to treatment in rare disease care.

Thoughtful, practical, and candid, this episode offers insight into multidisciplinary medicine, diagnostic humility, and caring for patients living with rare inflammatory diseases. It touches on the importance of being okay with uncertainty in the rare disease space.

Dr. Luke Chen is a hematologist and Professor of Medicine at Dalhousie University in Halifax, Nova Scotia. His clinical and research interests focus on rare inflammatory diseases and eosinophilic disorders. He is the founder of the Coastal Rare Inflammatory Diseases Program, supporting physicians caring for patients with rare diseases across Canada.

Around The Rheum is produced by the CRA Communications Committee. A special thank you to the podcast team, Dr. Dax G. Rumsey (CRA Communications Committee Chair), Dr. Daniel Ennis (Host), Dr. Janet Pope (Host), David McGuffin of Explore Productions, and Erin Stewart (CRA) for leading production.

Our theme music was composed by Aaron Fontwell.

For more on the work of the Canadian Rheumatology Association, visit rheum.ca.

In this episode, Dr. Proton Rahman reflects on his journey from patient with spondyloarthritis to internationally recognized rheumatologist and newly appointed member of the Order of Canada. He shares how his lived experience shapes his approach to patient care, offering insight into empathy, trust, and connection in chronic disease management.

Dr. Rahman also discusses the influence of key mentors — including Dr. Dafna Gladman, herself an Officer of the Order of Canada — in shaping his path into research and his work in the genetics of psoriatic arthritis and beyond! The conversation highlights the shift toward polygenic risk and the ongoing challenge of translating genetic discoveries into clinical practice.

Looking ahead, Dr. Rahman explores the future of rheumatology, emphasizing precision medicine, improved diagnostics, and more effective use of existing therapies. A thoughtful discussion on humility, mentorship, and the evolving complexity of modern rheumatology.

Dr. Proton Rahman is Clinical Chief of Rheumatology at Newfoundland and Labrador Health Services and John Lewis Distinguished Professor at Memorial University. A global expert in spondyloarthritis and psoriatic arthritis, his research focuses on the genetics of inflammatory arthritis and its translation into improved patient care. He is a recent appointee as a Member of the Order of Canada.

Around The Rheum is produced by the CRA Communications Committee. A special thank you to the podcast team, Dr. Dax G. Rumsey (CRA Communications Committee Chair), Dr. Daniel Ennis (Host), Dr. Janet Pope (Host) David McGuffin (exploreproductions.ca),

and Erin Stewart (CRA) for leading production.

Our theme music was composed by Aaron Fontwell.

For more on the work of the Canadian Rheumatology Association, visit rheum.ca

Hosts: Dr. Daniel Ennis, Dr. Janet Pope

Guests: Dr. Marinka Twilt (Pediatric Rheumatologist, University of Calgary; ASM Program Committee Chair), Dr. Mo Osman (University of Alberta; Abstract Chair & ASM Planning Committee Co-Chair)

We’re coming to you almost live from Halifax for Day 3—the final day of the Canadian Rheumatology Association ASM. The day featured strong podium presentations, a high-yield state-of-the-art lecture on Still’s disease, and a powerful closing keynote on health equity.

Podium sessions highlighted emerging science across the spectrum, including sex-based differences in psoriatic arthritis linked to genetic and epigenetic factors, novel monogenic variants in pediatric lupus with neurocognitive involvement, and ongoing inequities in access to therapies for JIA across provinces.

The state-of-the-art lecture on Still’s disease emphasized its spectrum across pediatric and adult care, with practical treatment strategies and increasing recognition of associated interstitial lung disease. Key points included the role of HLA-DRB1*15 as a risk marker, the importance of early treatment, and the potential for IL-1 and IL-6 therapies to contribute to complications in select patients.

Workshops reinforced these themes, focusing on practical approaches to diagnosing and managing Still’s disease, including lung involvement and the role of JAK inhibitors in refractory cases.

The meeting closed with a distinguished investigator lecture from Dr. Cheryl Barnabe, highlighting inequities in care for Indigenous populations and the importance of culturally safe, community-based care to address both geographic and systemic barriers.

Main Takeaways

• Genetic and epigenetic factors may explain sex differences in psoriatic arthritis
• Monogenic variants continue to reveal complexity in pediatric lupus
• Significant inequities persist in access to therapies for JIA across provinces
• Still’s disease spans pediatric and adult care with shared mechanisms
• HLA-DRB1*15 may help predict lung complications in Still’s disease
• Culturally safe, community-based care is essential to improving health equity

What’s Next

CRA ASM 2026 will be held in Vancouver.

More highlights coming next year—see you in Vancouver!