Are physical face scrubs damaging your skin barrier, and do you actually need that 10-step skincare routine? What does dermatological science actually say about your skincare routine?Join Jeroen Schreel and Aanchal Panth, a dermatologist at Dermafolix, as they break down the evidence-based truth behind anti-aging creams, snail mucin, and the biggest skincare mistakes people make every day.(00:00) Intro(00:28) Meet Dr. Aanchal Panth(00:45) The Biggest Skincare Scams: Physical Scrubs & Toners(02:15) Chemical vs. Physical Exfoliation: What Safely Removes Dead Skin(04:59) How to Identify Your Skin Type & Build a 3-Pillar Routine(07:32) Is Sunscreen Necessary Every Day? (Caucasian vs. South Asian Skin)(10:21) UV Light Therapy vs. Red Light LED Masks for Collagen(15:16) Botox Myths: When to Start & How Much Is Too Much?(18:24) Lifestyle Habits That Mirror Your Skin: Sleep, Diet & Exercise(20:58) Protein Intake, Carbohydrates & How Excess Salt Dulls Skin(23:37) Do Collagen & Hair Loss Supplements Actually Work?(28:44) Dangerous & Overrated Supplements: The Biotin Warning(29:49) Sleep Hygiene & How Strength Training Boosts Collagen(35:18) Skincare vs. Genetics: Why Our Ancestors Didn't Need Routines(36:51) The Ideal Minimalist Skincare Routine for Men (and Women)(42:25) What Is a Serum & How to Choose Active Ingredients(44:27) Anti-Aging Creams: What Can Actually Slow Down Wrinkling?(47:35) Trendy Skincare Devices: Microcurrents & At-Home Dermarollers(50:15) Does Snail Mucin Work? (The Wound-Healing Science)(52:21) Dr. Aanchal Panth's Personal Skincare Routine & Final AdvicePapers recommended by Aanchal:- Hussein et al., 2024. Influences on Skin and Intrinsic Aging: Biological, Environmental, and Therapeutic Insights. Journal of Cosmetic Dermatology, 24: Article e16688; https://doi.org/10.1111/jocd.16688- Kaltchenko and Chien, 2025. Photoaging: Current Concepts on Molecular Mechanisms, Prevention, and Treatment. American Journal of Clinical Dermatology, 26: pp. 321-344; https://doi.org/10.1007/s40257-025-00933-z- Rygula et al., 2024. Impact of Diet and Nutrition in Patients with Acne Vulgaris. Nutrients, 16: Article 1476; https://doi.org/10.3390/nu16101476- Ahmed and Mikail, 2024. Diet and skin health: The good and the bad. Nutrition, 119: Article 112350; https://doi.org/10.1016/j.nut.2023.112350- Devjani et al., 2023. Use of supplements for hair loss in skin of color patients. JAAD international, 12: pp. 182-183; https://doi.org/10.1016/j.jdin.2023.06.010- Singh et al., 2024. Snail extract for skin: A review of uses, projections, and limitations. Journal of Cosmetic Dermatology, 23: pp. 1113-1121; https://doi.org/10.1111/jocd.16269- Griffiths et al., 2023. Skin ageing and topical rejuvenation strategies. British Journal Of Dermatology, 189: pp. 17-23; https://doi.org/10.1093/bjd/ljad282- Siddiqui et al., 2024. Comparing Tretinoin to Other Topical Therapies in the Treatment of Skin Photoaging: A Systematic Review. American Journal of Clinical Dermatology, 25: pp. 873-890; https://doi.org/10.1007/s40257-024-00893-wDon't forget to join our monthly AFP newsletter: https://applefinchpudding.ck.page#Skincare #Dermatologist #AntiAging #Tretinoin #SkinCareScience #SciencePodcast #AppleFinchPudding

What if a wearable device could predict you’re getting sick days before you feel a single symptom?

Join Jeroen Schreel and Michael Snyder, a Professor of Genetics at Stanford University, as they delve into the future of medicine. Discover how a massive shift from reactive "sick-care" to proactive, personalized medicine is completely changing everything we know about human longevity, genetic biohacking, and tracking biomarkers in real time.

(00:00) Intro

(00:20) The Science of Accelerated Aging Peaks

(01:35) The Problem With Modern Healthcare

(04:00) What Is Proactive Medicine?

(06:30) How Wearables Detect Illness Early

(09:45) Continuous Biomarkers vs Yearly Blood Work

(13:10) The Role Of AI In Personalized Healthcare

(15:35) Stanford University Health Trials Overview

(18:50) DNA Sequencing And Disease Prevention

(22:25) Can We Extend Human Healthspan?

(26:00) The Science Of Longevity Explained

(29:35) Can Humans Live Forever?

(33:20) Psychological Impacts Of Immersive Seminars

(36:45) Clinical Trial Analysis: Intensive Psychosocial Interventions

(40:32) Physiology vs Traditional Learning Formats

(44:50) Future Of Digital Health Technology

These are some papers mentioned and/or recommended by Michael:- Shen et al., 2024. Nonlinear dynamics of multi-omics profiles during human aging. Nature Aging, 4: pp. 1619-1634; https://doi.org/10.1038/s43587-024-00692-2- Schüssler-Fiorenza Rose et al., 2019. A longitudinal big data approach for precision health. Nature Medicine, 25: pp. 792-804; https://doi.org/10.1038/s41591-019-0414-6- Dunn et al., 2021. Wearable sensors enable personalized predictions of clinical laboratory measurements. Nature Medicine, 27: pp. 1105-1112; https://doi.org/10.1038/s41591-021-01339-0- Li et al., 2017. Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information. PLoS Biology 15: Article e2001402; https://doi.org/10.1371/journal.pbio.2001402- Wu et al., 2025. Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology. Nature Medicine, 31: pp. 2232-2243; https://doi.org/10.1038/s41591-025-03719-2- Panyard et al., 2022. The metabolomics of human aging: Advances, challenges, and opportunities. Science Advances, 42: Article eadd6155; https://doi.org/10.1126/sciadv.add6155- Uwakwe et al., 2025. Longitudinal wearable sensor data enhance precision of Long COVID detection. PLoS Digital Health, 4: Article e0001093; https://doi.org/10.1371/journal.pdig.0001093- Wilson et al., 2021. Non-traditional immersive seminar enhances learning by promoting greater physiological and psychological engagement compared to a traditional lecture format. Psychology & Behavior, 238: Article 113461; https://doi.org/10.1016/j.physbeh.2021.113461- Ganz et al., 2022. Effects of an immersive psychosocial training program on depression and well-being: A randomized clinical trial. Journal of Psychiatric Research, 150: pp. 292-299; https://doi.org/10.1016/j.jpsychires.2022.02.034Michael's book: Genomics and Personalized Medicine: What everyone needs to knowFor more information on Michael's lab:https://med.stanford.edu/content/sm/snyderlab.html/

This is the supplement website Michael mentioned:

https://mysupplehub.org

Here you can learn more about the health trials running at Stanford University:

https://innovations.stanford.edu

Don't forget to join our monthly AFP newsletter: https://applefinchpudding.ck.page

#Longevity #PersonalizedMedicine #WearableTech #FutureOfMedicine #HealthScience #SciencePodcast

Did the universe really start with a massive explosion out of nothing? What if everything you were taught about the Big Bang in school is fundamentally wrong?Join Jeroen Schreel and Niayesh Afshordi, a Professor of physics and astronomy at the University of Waterloo, and research associate faculty at Perimeter Institute as they deconstruct the modern definition of the Big Bang, shifting away from the idea of a mathematical "singularity" where time stops, and looking at it like waking up from a cosmic dream. From cosmic inflation and primordial sound waves to mind-bending alternative models, like a cyclical "Big Bounce" or the hypothesis that our 3D reality emerged from a collapsing 5D star, this episode bridges the gap between popular myth and cutting-edge physics.

(00:00) Intro

(00:39) Ad

(02:44) Re-defining the Big Bang

(06:09) The Hawking & Penrose Singularity: Where the math of standard physics hits a limit

(07:54) Waking up from a cosmic dream: The modern scientific definition of our origins

(14:10) Archeology of the sky: Reading cosmic microwave background radiation and sound waves

(22:50) What is Cosmic Inflation? Solving the horizon problem

(35:33) The Varying Speed of Light theory vs. Inflation models

(36:30) Bouncing Narratives: Are we living in a cyclical universe?

(37:45) The 5D Star Hypothesis: Did our universe emerge from a higher-dimensional black hole?

(46:50) The Eternal Inflation Multiverse & String Theory: Elegance vs. testability

(57:50) The Copenhagen Survey: Testing what world-class physicists actually believe

(01:03:15) Changing your mind in physics: Why science makes progress "one funeral at a time"

Papers recommended by Niayesh:- Hu and Dodelson, 2002. Cosmic Microwave Background Anisotropies. Annual Review of Astronomy and Astrophysics, 40: pp. 171-216; https://doi.org/10.1146/annurev.astro.40.060401.093926- Guth, 1981. Inflationary universe: A possible solution to the horizon and flatness problems. Physical Review D, 23: pp. 347-356; https://doi.org/10.1103/PhysRevD.23.347- Akrami et al., 2019. Planck 2018 results - X. Constraints on inflation. Astronomy & Astrophysics, 641: Article A10; https://doi.org/10.1051/0004-6361/201833887- Borde et al., 2003. Inflationary Spacetimes Are Incomplete in Past Directions. Physical Review Letters, 90: Article 151301; https://doi.org/10.1103/PhysRevLett.90.151301- Albrecht and Magueijo, 1999. Time varying speed of light as a solution to cosmological puzzles. Physical Review D, 59: Article 043516; https://doi.org/10.1103/PhysRevD.59.043516- Brandenberger and Peter, 2017. Bouncing Cosmologies: Progress and Problems. Foundations of Physics, 47: pp. 797-850; https://doi.org/10.1007/s10701-016-0057-0- Pourhasan et al., 2014. Out of the white hole: a holographic origin for the Big Bang. Journal of Cosmology and Astroparticle Physics, 2014: Article 1309.1487; http://dx.doi.org/10.1088/1475-7516/2014/04/005- Guth, 2007. Eternal inflation and its implications. Journal of Physics A: Mathematical and Theoretical, 40: Article 6811; https://doi.org/10.1088/1751-8113/40/25/S25- Chen et al., 2025. Copenhagen Survey on Black Holes and Fundamental Physics. Preprint; https://doi.org/10.48550/arXiv.2503.15776- Afshordi et al., 2026. Big Mysteries Survey: Physicists' Views on Cosmology, Black Holes, Quantum Mechanics, and Quantum Gravity. Preprint; https://doi.org/10.48550/arXiv.2605.11058

This episode is sponsored by ResearchRabbit

https://www.researchrabbit.ai

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#BigBang #Astrophysics #Cosmology #Physics #SciencePodcast