Age-Related Macular Degeneration as a Disease of Retinal Metabolic Failure
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Age-Related Macular Degeneration as a Disease of Retinal Metabolic Failure
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Age-related macular degeneration is usually described as a problem of aging and drusen. But a growing body of research points to something deeper: a slow failure of energy metabolism in the retina and the cells that support it. In this episode, Dr. Saikumar Gandapodi, Founder and Director of Netra Eye Institute, reframes AMD as a disease of metabolic exhaustion in the retinal pigment epithelium and photoreceptors.
We explore why the macula is metabolically the most demanding tissue in the body, how mitochondrial dysfunction, oxidative stress, and lipid handling failures set the stage for drusen and cell death, and what conventional care does well. Dr. Gandapodi explains the evidence behind anti-VEGF therapy and the AREDS trials, and where meaningful gaps remain.
He also introduces Netra Restoration Therapy, an integrative, adjunct approach aimed at supporting mitochondrial function, oxidative balance, and ocular blood flow. Throughout, the conversation stays honest about what is established, what is emerging, and what remains hypothesis.