There is a huge amount we can learn from understanding the connections between soil health, food production, and human metabolic health. Over the last 50-60 years, modern agricultural systems have become increasingly reliant on synthetic inputs that boost yields but degrade soil microbiomes and reduce micronutrient density in our food. This degradation contributes to the chronic disease epidemic costing the United States trillions of dollars annually.

The impact of regenerative agriculture on both environmental and human health cannot be understated. Healthier soils with robust microbiomes produce crops with superior nutritional profiles—more micronutrients and beneficial phytochemicals that express through the soil-plant-human pathway. When people consume these nutrient-dense foods, they show reduced appetite for processed foods and better metabolic outcomes, though randomized controlled trials remain limited.

Today we are joined by Carter Williams from iSelect Fund, a 10-year-old investment firm focused on reducing chronic disease by transforming food systems. Williams coordinates investments across the food value chain—from row crop biologics to novel sweeteners and soil health monitoring.

iSelect Fund targets decommoditizing 5-10% of conventional agriculture rather than wholesale transformation, creating price premiums for regenerative producers while stabilizing markets for conventional farmers. The fund prioritizes nutrient density over yield maximization.

Williams identifies cognitive load as agriculture's fundamental transformation challenge. Farmers with 20 years of conventional experience face learning entirely new systems. This extends throughout supply chains: CPG companies have infrastructure optimized for current grain varieties; input companies have systems built around synthetic fertilizer. Even willing stakeholders face substantial cognitive and financial investment requirements.

The conversation explores modernizing Bureau of Land Management grazing practices. Research showing $200-300 million in upstream regenerative interventions could have prevented $10 billion in European flood insurance losses demonstrates how regenerative livestock management delivers net carbon-positive outcomes while improving rancher economics.

Emerging feedback mechanisms accelerate adoption. Companies like Diatious provide data showing how feeding practices affect omega-3/omega-6 ratios, enabling evidence-based practice changes. Companies like Brightseed build in-silico models mapping how growing practices affect phytochemical expression and human metabolism.

Williams argues consumer voice—amplified by influencers—now drives change more effectively than the previous decade's farmer-led push. As retailers stock out of cottage cheese due to GLP-1 diet trends rather than label-reading, market dynamics shift faster than Nielsen surveys suggested possible.

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Currently beef cattle production faces a profitability challenge driven by rising feed costs and efficiency gaps. For cow-calf operations, particularly where producers operate on forage-based systems, the biggest variable cost is cow feed, yet geneticists lack precise selection tools for measuring and improving forage intake and conversion efficiency.

Today we are joined by Troy Rowan from the University of Tennessee, where he investigates economically important traits in beef cattle with particular emphasis on cow efficiency, local adaptation, and genetic approaches to increasing sustainability. His research focuses on developing novel measurement approaches to create practical selection tools for grazing efficiency.

The opportunity lies in emerging technologies. While decades of work developed feed efficiency tools for concentrate-fed feedlot environments, these measurements don't translate to grazing systems. Rowan's team explores indicators serving as stand-ins in genetic evaluations, using emissions as metabolic proxies, leveraging precision technologies like AI and computer vision to capture phenotypes previously impractical to measure on large animal groups.

Methane and CO2 are important because they are the best indicator of metabolism currently available. Even though they are imperfect metabolism needs to be included to provide an indicator for cow feed costs.

Looking forward, epigenetics and other "omics" technologies promise to revolutionize individual animal management. Rather than just predicting genetic potential passed to offspring, these tools could enable phenotypic predictions based on epigenetic marks, gene expression, or metabolomics. A feedlot receiving heterogeneous cattle could place animals in appropriate pens and management protocols based on predicted disease resistance, growth potential, or feed efficiency—filling in the 70% of trait variation that genetics alone doesn't capture. After measuring 10,000-plus animals to develop robust genetic evaluations, the next frontier is translating that knowledge into practical tools that work across the one the billion plus cattle worldwide, from intensive North American operations to pastoral African systems where data recording infrastructure remains the primary bottleneck.

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Over the last century our food systems have become increasingly reliant on synthetic nitrogen. This nitrogen fertilizer is mostly made through the energy intensive haber-bosch process in centralized production plants, often located in politically sensitive location, that have a carbon footprint multiple times greater than the aviation industry.

Today we are joined by Frere Byrne of PlasmaLeap Technologies who is developing low cost mobile technology to systhesis zero emissions ammonia from air and water. I caught up with Frere to discuss the impact of locally produced nitrogen that is not relaint on fossil feuls and long and centralized supply chains

PlasmaLeap's modular chemical plants—called NFix—operate as single 40-foot containerized units producing industrial-grade nitrates and ammonia from air, water, and renewable electricity. These units run autonomously using algorithms, requiring no specialized operators and can be controlled remotely from company desks. For large-scale applications, units stack like batteries to create regional facilities. For smallholder farmers, Plasma Leap has developed miniature versions funded through a Gates Foundation grant, targeting production costs below the lowest commodity urea prices of the past 20-30 years.

The technology addresses identical challenges across vastly different farming contexts. Whether a one-hectare subsistence farm in sub-Saharan Africa or a 100,000-hectare cereal operation in Australia, farmers face volatile input prices, intermittent supply chains, and little control over product quality.

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