Natalie Sykes spent years using heroin and crack cocaine to self-medicate undiagnosed PMDD, autism and ADHD, and now finally understands why.

Natalie, founder of the PMDD & Neurodivergence Alliance, tells Dr Louise Newson how PMDD's crushing hormonal mood swings collided with undiagnosed autism and ADHD to leave her, in her words, "allergic to my own body." Misdiagnosed as bipolar for decades, she turned to substances that numbed what nobody could explain. While using heroin, her PMDD symptoms disappeared completely.

Louise explains that progesterone, estradiol and testosterone act directly on the brain's opioid and dopamine receptors, so when women are chronically short of these hormones, the body looks for relief elsewhere. They discuss why neurodivergent women are especially vulnerable to this pattern and why harm reduction has to be part of the conversation.

Natalie shares her three take-home tips for anyone who suspects PMDD, ADHD or autism might be behind their struggle to cope.

If you've experienced hormonal changes at any stage of life - from menstruation through to menopause - and have experience of addictive behaviours, coping strategies or gambling, you can help shape future support by taking part in this research survey: https://newson.qualtrics.com/jfe/form/SV_1YtaHkftP8GrSbc

Follow Natalie @pmddneurodivergencealliance

Let’s connect👉 Been dismissed or misdiagnosed? Book a consultation at Newson Health clinic: https://www.newsonhealth.co.uk/consultations👉 More from Dr Louise Newson: https://linkin.bio/drlouisenewson👉 Follow Natalie's work with the PMDD & Neurodivergence Alliance: https://www.facebook.com/share/1CzUafKyFt/?mibextid=wwXIfr