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Charlie has been gathering some of the best scientists in the world to rethink what agency is together and form new connections outside the usual academic constraints

Join Andrea in NYC this week here.

Today's guest is Charlie Munford, president of the Agential Biology Institute, and he has been gathering some of the best scientists and philosophers in the world together to rethink agency. Andrea and Charlie have a personal, meandering conversation that moves from family life stories to foundational questions in biology, education, evolution, and meaning. Munford recounts growing up in Mississippi, wilderness canoe trips, Yale literature and polo, organic agriculture studies in Cuba, farming and a New Orleans wild boar sausage business, and a later personal crisis that pushed him into researching chronic disease and biological agency. He argues mainstream gene-centered biology assumes blind variation, but evidence for inherited acquired changes and directional adaptation (horizontal gene transfer, planaria pattern memory, small-RNA inheritance in worms and mammals, maternal grooming effects, genetic assimilation) suggests a missing causal layer and universal cellular learning. They discuss natural selection, Darwin and Lamarck, Barbara McClintock, a Karl Popper “active Darwinism” lecture, ABI’s testable hypotheses, and openness, creativity, and care.

00:00 Welcome and Brooklyn Invite
04:20 Meet Charlie Munford
04:35 Banana Couch Story
05:49 Kids and Creativity
08:48 Mississippi to Yale Adventures
15:17 Farming Cuba and Sausage Business
18:40 Crisis Sparks Biology Questions
21:38 Agential Biology Explained
30:04 Lamarck Darwin and Natural Selection
36:45 Evidence for Inherited Change
46:21 McClintock and Popper Teaser
47:51 Cells Sense Not Code
48:36 Genes Aren't Difference Makers
49:45 Popper Versus Selfish Gene
54:06 Agency Without Theology
55:11 Horizontal Gene Transfer
58:34 Three Testable Agency Ideas
01:00:00 Popper And Falsification
01:06:05 Episolution And Cellular Mind
01:12:58 Harmonic Resonance And Sleep
01:17:12 Attention And Surprise Learning
01:20:33 Personal Journey And Meaning
01:26:24 Love Openness And Invitation
01:30:16 Otter Story Farewell

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