The San Francisco 49ers take on the Indianapolis Colts in apivotal Week 16 matchup with massive playoff implications. Riding a four-game winning streak, the 49ers need just one more win to clinch a playoff spot — but the Colts are desperate to keep their slim postseason hopes alive.

In this podcast, we break down how Brock Purdy and the 49ers offense match up against a Colts defense that’s been vulnerable through the air, and whether San Francisco’s struggling run defense can slow down NFL rushing leader Jonathan Taylor.

We also dive into Philip Rivers’ role as a point-guard quarterback, key injury storylines, trench battles, and why tackling will decide this game.

Will the 49ers continue their improbable playoff push, orwill the Colts play spoiler in Week 16?

Topics Covered:

• 49ers vs. Colts Week 16 preview
• NFL Playoff scenarios & clinching paths
• Brock Purdy matchup breakdown
• Jonathan Taylor vs. 49ers run defense
• George Kittle & 49ers' passing advantages
• Keys to victory and final prediction

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