18 Pharmacology Red Flags With 1 Simple & Clear Action for each
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1. Opioids – Respiratory DepressionRed Flag: Respiratory rate below 8–10
Action: Stop the infusion immediately, administer naloxone, monitor closely for re-sedation.
Red Flag: Platelets below 100,000
Action: Stop heparin immediately, notify provider, avoid antiplatelets.
Red Flag: INR above 3.5–4 or any active bleeding
Action: Hold the dose, give vitamin K (planned) or FFP (active bleed).
Red Flag: Yellow/green halos, heart rate below 60, significant nausea
Action: Hold digoxin, draw serum level before considering antidote.
Red Flag: Severe burning, rhythm changes, undiluted infusion
Action: Stop the infusion instantly.
Red Flag: Intense flushing and rash during infusion
Action: Slow the infusion, pre-treat with diphenhydramine for future doses.
Red Flag: Purple, swollen, painful IV site
Action: Stop the infusion, use slow rate and inline filter for prevention.
Red Flag: Rapid swelling of lips, tongue, or face
Action: Stop the drug immediately, never restart ACE inhibitors.
Red Flag: New tinnitus or hearing loss
Action: Stop the medication, check peak and trough levels.
Red Flag: Coarse tremor, confusion, severe nausea
Action: Hold the dose, check level, increase fluids.
Red Flag: High fever, agitation, rigidity, hyperreflexia
Action: Stop the medication immediately, initiate cooling and supportive care.
Red Flag: Child with viral illness taking NSAIDs/aspirin
Action: Stop immediately, switch to acetaminophen.
Red Flag: Upcoming contrast study or muscle pain/drowsiness
Action: Hold 48 hours before and after contrast.
Red Flags: Respiratory rate below 12, absent DTRs, low urine output
Action: Stop magnesium, give calcium.
Red Flag: Heart rate below 50–60 with symptoms
Action: Hold dose, notify provider; glucagon for severe overdose.
Red Flag: Scheduled surgery within 3–5 days
Action: Hold medication pre-op (5 days for clopidogrel, 3–5 for ticagrelor).
Red Flag: Persistent dry cough, new shortness of breath, abnormal chest image
Action: Stop amiodarone, start steroids.
Red Flag: Burning, swelling, pain at IV site
Action:
Stop the infusion
Do NOT remove the IV
Aspirate the drug
Remove needle
Apply cold (or heat for vinca alkaloids)
Give antidote
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