#Ozempic #Mounjaro #GLP1 #WeightLoss #obesitymedicine

Ozempic and Mounjaro are two of the most powerful tools we've ever had for weight loss and metabolic health — but what you combine them with matters. In this video, Dr. Mohammed Paika, MD (board-certified in Internal Medicine and Obesity Medicine, hospitalist for nearly 20 years) breaks down 10 medications, substances, and habits that can quietly work against your GLP-1 treatment: SGLT2 inhibitors, metformin, cannabis/THC, artificial sweeteners and sugar alcohols, compounded/gray-market GLP-1 products, skipping resistance training, SSRIs, caffeine, diuretics, and stacking multiple GLP-1 medications. You'll learn the actual physiology behind each risk, real warning signs to watch for, and what to do instead — so your treatment stays safer, easier to stick with, and more effective.

🎓 Complete GLP-1 Weight Loss Masterclass — Lifetime Access
Comprehensive education on GLP-1 medications, nutrition, exercise, muscle preservation, side effects & long-term success. Includes the companion eBook, quizzes, 12-week exercise program, certificate & future course updates at no additional cost.
https://www.drmohammedpaika.com

📩 FREE GLP-1 Diet Cookbook + Weekly Newsletter
Get weekly evidence-based insights on GLP-1s, metabolic health, nutrition, exercise & longevity.
https://www.drmohammedpaika.com/newsletter

📚 The Weight Equation & The Physician’s Physique
Physician-written, evidence-based guides to obesity, weight loss, nutrition, metabolism, exercise, body composition & healthier living.
https://www.drmohammedpaika.com/books

👥 Metabolic Health Community
Live Q&As, evidence-based education, accountability, workouts, nutrition guidance & community support.
https://www.skool.com/metabolic-health-community-5316

Timestamps
0:00 Intro — Why This List Matters
0:42 Meet Dr. Paika + The Ground Rule
1:50 #1 SGLT2 Inhibitors (Euglycemic DKA Risk)
4:34 #2 Metformin
6:59 #3 Cannabis & THC Products
9:12 #4 Artificial Sweeteners & Sugar Alcohols
11:37 Quick Break + Free Resources
13:04 #5 Compounded/Gray-Market GLP-1s
15:25 #6 Skipping Resistance Training
17:57 #7 SSRIs & Serotonergic Medications
20:03 #8 Caffeine
22:12 #9 Diuretics
24:37 #10 Stacking Multiple GLP-1 Medications
26:58 The Bottom Line
27:32 What to Watch Next

Sources & References:
Ozempic (semaglutide) FDA label — https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/209637s035,209637s037lbl.pdf
Mounjaro (tirzepatide) FDA label — https://www.accessdata.fda.gov/drugsatfda_docs/label/2026/215866s041lbl.pdf
SGLT2 inhibitors + GLP-1 → euglycemic DKA — https://pmc.ncbi.nlm.nih.gov/articles/PMC11454998/
Metformin + GLP-1 GI overlap (Diabetes Care) — https://diabetesjournals.org/care/article/47/2/280/153929/
Cannabinoid Hyperemesis Syndrome (StatPearls) — https://www.ncbi.nlm.nih.gov/books/NBK549915/
Sweeteners & gut microbiome (Nature) — https://www.nature.com/articles/nature13793
FDA alert: compounded semaglutide dosing errors — https://www.fda.gov/drugs/human-drug-compounding/fda-alerts-health-care-providers-compounders-and-patients-dosing-errors-associated-compounded
Protein + resistance training for muscle preservation (BJSM) — https://pubmed.ncbi.nlm.nih.gov/28698222/
FDA removes GLP-1 suicidality warning — https://www.fda.gov/drugs/drug-safety-communications/fda-requests-removal-suicidal-behavior-and-ideation-warning-glucagon-peptide-1-receptor-agonist-glp
Caffeine & gastric acid secretion (PNAS) — https://www.pnas.org/doi/10.1073/pnas.1703728114
FDA kidney injury warning, GLP-1-related dehydration — https://healthesystems.com/workerscomprehensive/fda-requires-new-kidney-injury-warning-for-all-glp-1-drugs/
GLP-1/GIP/glucagon receptor pharmacology (tirzepatide, retatrutide) — https://www.nature.com/articles/s41421-024-00700-0

⚕️ MEDICAL & EDUCATIONAL DISCLAIMER⚕️ MEDICAL & EDUCATIONAL DISCLAIMER
This content is for general educational and informational purposes only and is not medical advice or a substitute for care from your healthcare provider. Viewing this content does not create a doctor-patient relationship with Dr. Mohammed K. Paika. Always consult your healthcare provider before making changes to medications, diet, exercise, or weight-loss treatment, including GLP-1 therapies. Individual risks and results vary.