For centuries, drug discovery was a slow, trial-and-error process—sometimes taking decades to develop life-saving treatments. But what if we could speed up that timeline? At Lawrence Livermore National Laboratory, scientists are using supercomputing, machine learning, and AI to revolutionize how new medicines are found, tested, and developed.

In this episode, we dive into the cutting-edge technology behind faster drug discovery, how researchers are using high-performance computing to target diseases more precisely, and the potential to bring new treatments—from cancer drugs to viral countermeasures—to patients in record time.

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Big Ideas Lab is a Mission.org original series.

Executive Produced by Lacey Peace and Levi Hanusch.

Sound Design, Music Edit and Mix by Daniel Brunelle.

Story Editing by Daniel Brunelle.

Audio Engineering and Editing by Matthew Powell.

Narrated by Matthew Powell.

Video Production by Levi Hanusch.

Guests featured in this episode (in order of appearance):

• Jim Brase, Deputy Associate Director for Computing, Lead of the Bio Resilience Initiative, LLNL
• Felice Lightstone, Leader, Biochemical and Biophysical Systems Group, LLNL
• Jonathan Allen, Informatics Scientist, LLNL

Brought to you in partnership with Lawrence Livermore National Laboratory.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Inside the National Ignition Facility, 192 laser beams push the limits of science and technology, supporting critical national security and scientific research. But the extreme energy takes a toll, leaving tiny cracks and damage on the system’s delicate optics.

Instead of replacing these costly components, scientists at Lawrence Livermore National Laboratory have developed a high-tech repair process: the Optics Recycle Loop. Like a Formula 1 pit stop for lasers, this system inspects, restores, and reintegrates damaged optics with precision—keeping NIF firing at peak performance.

In this episode, we explore how researchers extend the life of these vital components, the cutting-edge science behind laser damage repair, and why maintaining NIF’s optics is key to its success.

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Big Ideas Lab is a Mission.org original series.

Executive Produced by Lacey Peace and Levi Hanusch.

Sound Design, Music Edit and Mix by Daniel Brunelle.

Story Editing by Daniel Brunelle.

Audio Engineering and Editing by Matthew Powell.

Narrated by Matthew Powell.

Video Production by Levi Hanusch.

Guests featured in this episode (in order of appearance):

• Tayyab Suratwala, Program Director for Optics and Materials Science, LLNL
• Laura Mascio Kegelmeyer, Former NIF Team Leader for Optics Inspection and Data Management, LLNL
• Wren Carr, Science and Technology Leader for the Optical and Material Science and Technology Group, LLNL

Brought to you in partnership with Lawrence Livermore National Laboratory.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Asteroids have reshaped Earth before—and scientists know another impact is inevitable. When traditional deflection methods won’t work, what’s the last resort?

At Lawrence Livermore National Laboratory, experts are exploring nuclear deflection: using nuclear energy to alter an asteroid’s path or break it apart before impact. But how does it work, what are the risks, and how prepared are we to use it when the time comes?

This is the second episode in our Planetary Defense series.
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Big Ideas Lab is a Mission.org original series.

Executive Produced by Lacey Peace and Levi Hanusch.

Sound Design, Music Edit and Mix by Daniel Brunelle.

Story Editing by Daniel Brunelle.

Audio Engineering and Editing by Matthew Powell.

Narrated by Matthew Powell.

Video Production by Levi Hanusch.

Guests featured in this episode (in order of appearance):

• Cody Raskin, Design Physicist, LLNL
• Mary Burkey, Staff Scientist, LLNL
• Mike Owen, Computational Physicist, LLNL

Brought to you in partnership with Lawrence Livermore National Laboratory.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In 2013, a house-sized asteroid exploded over Chelyabinsk, Russia, with the force of 30 atomic bombs. A century earlier, an asteroid impact flattened 830 square miles of Siberian forest. And while Hollywood loves to dramatize asteroid threats, the real work of planetary defense isn’t happening in action movies—it’s happening in research labs.

At Lawrence Livermore National Laboratory, a team of scientists is racing against time to track, deflect, and prepare for the next asteroid threat. They’re using cutting-edge simulations, kinetic impact tests, and global collaborations to ensure Earth is ready before disaster strikes. In this episode, we uncover how planetary defense has evolved from theory to reality—why asteroid threats are more real than most people think—and what it will take to stop a civilization-ending impact.

Because the next asteroid isn’t a question of if—but when.

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Big Ideas Lab is a Mission.org original series.

Executive Produced by Lacey Peace and Levi Hanusch.

Sound Design, Music Edit and Mix by Daniel Brunelle.

Story Editing by Daniel Brunelle.

Audio Engineering and Editing by Matthew Powell.

Narrated by Matthew Powell.

Video Production by Levi Hanusch.

Guests featured in this episode (in order of appearance):

• Jason Pearl, Physicist at the Planetary Defense Group, LLNL
• Megan Bruck Syal, Former Leader of the Planetary Defense Program, LLNL
• Katie Kumamoto, Leader of the Planetary Defense Program, LLNL

Brought to you in partnership with Lawrence Livermore National Laboratory.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

How do you maintain a facility built to achieve the impossible? In this episode, we explore the National Ignition Facility Sustainment Project—an undertaking to ensure that the world’s most energetic laser continues to deliver on its mission. Discover how scientists at the National Ignition Facility keep this technological marvel running, overcoming challenges of aging systems to ensure it remains a cornerstone of innovation and a vital asset to the nation’s security.

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Big Ideas Lab is a Mission.org original series.

Executive Produced by Lacey Peace and Levi Hanusch.

Sound Design, Music Edit and Mix by Daniel Brunelle.

Story Editing by Daniel Brunelle.

Audio Engineering and Editing by Matthew Powell.

Narrated by Matthew Powell.

Video Production by Levi Hanusch.

Guests featured in this episode (in order of appearance):

• Jean Michel Di Nicola, Co-Program Director for Laser Science and Systems Engineering at NIF, LLNL
• Gordon Brunton, National Ignition Facility Director, LLNL
• Jeff Horner, Project Manager for the NIF Sustainment Project, LLNL
• Larry Pelz, Deputy Group Leader for Laser Science Systems Engineering, LLNL

Brought to you in partnership with Lawrence Livermore National Laboratory.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The ground beneath us is always moving—but what can it reveal about our future? At Lawrence Livermore National Laboratory, seismic monitoring has evolved into a cornerstone of national security and disaster preparedness. From detecting nuclear tests halfway across the globe to simulating the devastating effects of earthquakes before they strike, this episode explores how LLNL’s work is making the world a safer place—one seismic wave at a time.

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Big Ideas Lab is a Mission.org original series.

Executive Produced by Lacey Peace.

Sound Design, Music Edit and Mix by Daniel Brunelle.

Story Editing by Daniel Brunelle.

Audio Engineering and Editing by Matthew Powell.

Narrated by Matthew Powell.

Video Production by Levi Hanusch.

Guests featured in this episode (in order of appearance):

• Bill Walter, Geophysical Monitoring Programs Focus Area Lead, LLNL
• Arben Pitarka, Seismology Group Leader, LLNL

Brought to you in partnership with Lawrence Livermore National Laboratory.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

What happens when you bring a group of fifth graders into one of the world’s most advanced science labs? It’s not just magic—it’s mission-critical.

At Lawrence Livermore National Laboratory, student outreach programs, from elementary school activities to graduate internships, are designed to spark curiosity and foster a lifelong love of science. These programs aren’t just about teaching; they’re about preparing the U.S. to tackle tomorrow’s greatest challenges. With the global stakes higher than ever, hear how sparking curiosity in young minds today is essential to developing the innovators, engineers, and problem-solvers who will lead the world tomorrow.

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Big Ideas Lab is a Mission.org original series.

Executive Produced by Lacey Peace.

Sound Design, Music Edit and Mix by Daniel Brunelle.

Story Editing by Daniel Brunelle.

Audio Engineering and Editing by Matthew Powell.

Narrated by Matthew Powell.

Video Production by Levi Hanusch.

Guests featured in this episode (in order of appearance):

• Joanna Albala, Science Education Programmer at LLNL
• Patrick Poole, Experimental Physicist at LLNL

Brought to you in partnership with Lawrence Livermore National Laboratory.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Entire communities erased by hurricanes. 240,000 square kilometers burned. Floodwaters swallowing towns. Extreme weather isn’t a distant threat—it’s reshaping our world. But here’s the good news: we’re not powerless. Enter the Roads to Removal report, a new strategy for combating climate change.

In this episode, we delve into the science, strategy, and stories behind this effort. Join us as we explore how scientists, farmers, and policymakers are uniting to turn the tide on climate change.

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Big Ideas Lab is a Mission.org original series.

Executive Produced by Lacey Peace.

Sound Design, Music Edit and Mix by Daniel Brunelle.

Story Editing by Daniel Brunelle.

Audio Engineering and Editing by Matthew Powell.

Narrated by Matthew Powell.

Video Production by Levi Hanusch.

Guests featured in this episode (in order of appearance):

• Jennifer Pett-Ridge, Lead of the LLNL Carbon Initiative
• Simon Pang, Associate Group Leader in the Materials for Energy and Climate Security Group at LLNL
• Kimberley Mayfield, Staff Scientist of Energy Equity & Carbon Management at LLNL

Brought to you in partnership with Lawrence Livermore National Laboratory.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.