Longevity has gone viral. After years as a somewhat obscure scientific backwater, the science – and science fiction – of living far longer has captured the imagination of millions. From restricted diets and biological aging clocks to repurposed drugs to groundbreaking new paradigms, the field has spawned multi-billion dollar hopes and hypes. Underlying all this excitement is a complex biological network of molecules, that sets the pace of aging. While we know relatively little about this longevity network, there exists the tantalizing possibility that tweaking just a few, select nodes could help us live longer and healthier lives.

Recent research has coalesced around a dozen distinct age-related changes seen in all animals and even simple, single celled organisms, known as the Hallmarks of Aging. In many cases, modifying one Hallmark causes ripple effects throughout the entire aging network, sometimes allowing a single gene or a single molecule, like rapamycin, to have such profound and far-reaching effects on the entire biological aging process.

But how do we discern promising antiaging candidates in this sea of noise and stay clear of the snake oil? The Longevity Formula distils the essential science, laced with rich personal stories behind the discoveries, into a lucid saga detailing where longevity medicine is headed. It concludes by presenting the best science-backed recipes to support a healthy, long life.

© Matt Kaeberlein and Ram Hariharan 2027 (P) Penguin Audio 2027