Why do some people seem twenty years younger than their actual age while others decline rapidly despite similar lifestyles? Dr. Matt Kaeberlein is one of the leading researchers in the biology of aging whose work has shaped geroscience and given executives clarity on what actually drives cellular decline versus supplement industry noise. Dogs age biologically seven times faster than humans, proving aging rates are modifiable through specific biological pathways.

In this episode of the Legacy and Longevity Podcast with host Zach Dancel, Dr. Matt Kaeberlein reveals why the mTOR pathway controls whether cells prioritize growth or stress resistance affecting all hallmarks of aging simultaneously, how rapamycin slows aging in every animal tested despite physician hesitation around high-dose transplant medicine versus once-weekly protocols. On why comprehensive blood work plus DEXA scans matter more than biological age clocks, explains diet quality trumps intermittent fasting timing for metabolic optimization, and shares how AI health agents arriving within two years will scale personalized interventions currently limited to wealthy populations. Fifteen additional years of health span are available using today's science for leaders willing to act proactively instead of reactively.

Discover how to align your biology with circadian rhythms and build a health span that matches your lifespan. Stop managing symptoms—start mastering your health with daily habits that transform your biology. Discover your path to peak health; to know more, click on the link below:

Follow Legacy and Longevity Podcast:

Website: LegacyandLongevity.com | Facebook: Legacy-and-Longevity-Podcast | YouTube: @LegacyandLongevityPodcast | Instagram: @LegacyandLongevity

Follow Zach Dancel:

Instagram: @ZachDancel | Facebook: Zach.Dancel | LinkedIn: @ZachDancel

Follow Dr. Matt Kaeberlein:

LinkedIn: @MKaeberlein | YouTube: @OptiSpan | Twitter/X: @MKaeberlein | Website: OptiSpan.life