Most anti-aging skincare is focused on the surface — but the real story of skin aging starts much deeper. Mayo Clinic dermatologist Dr. Saranya Wyles breaks down what’s actually happening beneath your skin, why up to 75% of skin aging may be modifiable, and what science really says about retinol, SPF, red light therapy, collagen, peptides, GLP-1s, and more.

Saranya Wyles, MD, PhD, is the Director of the Regenerative Dermatology and the Skin Longevity Laboratory at Mayo Clinic whose work focuses on skin aging, wound healing, cellular senescence, and regenerative medicine. In this episode of The LIVING Room Podcast, she joins Chris Wharton to explain why your skin is often a reflection of what’s happening inside your body — from brain health to heart health and overall aging, what SPF, retinol, red light therapy, collagen, and peptides actually do, and why the future of skincare will include 3D-bioprinted skin tissue and regenerative therapies.

What we cover in this conversation:

• Why 75% of skin aging is modifiable — and what that actually means
• The skincare routine a Mayo Clinic dermatologist actually recommends
• Why oral collagen supplements may be a waste of money
• Whether retinol, red light therapy, and peptides live up to the hype
• What sunscreen actually protects you from (and how it impacts vitamin D)
• Why weight-loss drugs like GLP-1s may be aging your face
• The future of regenerative skin repair — from exosomes to 3D-bioprinted skin

For science-backed clarity on what really protects your skin, free from the noise of anti-aging marketing — this episode delivers true value around powerful anti-aging practices that you can apply to your life.

Learn more about Dr. Saranya Wyles https://www.instagram.com/drwyles.derm