Kabuto is a highly skilled assassin eager to escape his dangerous profession and the hold his handler, the sinister Doctor, has over him. The Doctor, a real physician who hands over Kabuto’s targets as “prescriptions” in his regular appointments with him, doesn’t want to lose Kabuto as a profitable asset, but he agrees to let him pay his way out of his employment with a few last jobs. Only the most lucrative jobs involve taking out other professional assassins, and Kabuto’s final assignment puts him and his family—who have no idea about his double life—in danger.

He is a brilliant math professor with a peculiar problem - ever since a traumatic head injury, he has lived with only 80 minutes of short-term memory. She is an astute young housekeeper - with a 10-year-old son-who is hired to care for the professor. And every morning, as the professor and the housekeeper are introduced to each other anew, a strange and beautiful relationship blossoms between them.

Tokyo resident Keiko Furukara has never fit in - neither in her family, nor in school - but when at the age of 18 she begins working at the Hiiromachi branch of national convenience store chain Smile Mart, she realizes instantly that she has found her purpose in life. Delighted to be able to exist in a place where the rules of social interaction are crystal clear (many are laid out line-by-line in the store's manual), Keiko does her best to copy the dress, mannerisms, and mode of speech of her colleagues, playing the part of a "normal" person excellently, more or less.

Sentaro has failed. He has a criminal record, drinks too much, and his dream of becoming a writer is just a distant memory. With only the blossoming of the cherry trees to mark the passing of time, he spends his days in a tiny confectionery shop selling dorayaki, a type of pancake filled with sweet bean paste. Into his life comes Tokue, an elderly woman with disfigured hands and a troubled past. Tokue makes the best sweet bean paste Sentaro has ever tasted. She begins to teach him her craft, but as their friendship flourishes, social pressures become impossible to escape.

As a child, Natsuki doesn’t fit into her family. Her parents favor her sister, and her best friend is a plush toy hedgehog named Piyyut who has explained to her that he has come from the planet Popinpobopia on a special quest to help her save the Earth.